Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical Tools

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CRC Press, May 19, 1994 - Medical - 560 pages
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Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.
  

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Contents

Hair Follicle Stem Cells
30
The Mouse Skin as a Model for Chemical Carcinogenesis
39
Viral Induced Skin Tumors in Mice
47
Hair Types and Subtypes in the Laboratory Mouse
57
Growth Factors and Cutaneous Pathology
69
Transgenic Mice with Cytokine Mutations Affecting the Skin
81
Epidermal Keratins
95
Hair Follicle Keratins
105
The Ferrochelatase Deficiency Fechm1ps Mutation
247
The Flaky Tail ft Mutation Chromosome 3
269
The Greasy Gs Mutation Chromosome X
285
The Hair Patches Hpt Mutation Chromosome 4
313
The Ichthyosis ic Mutation Chromosome 1
327
The Lustrous It Mutation Chromosome 11
343
The mammalian hair cycle is a fascinating example of tissue development and remodeling that
345
Mottled Mo Blotchy Moht Brindled Mohr
359

Keratinocyte Cultures as Models for Dermatological Disease
117
Mouse Mutations with Endocrine Functional Consequences
129
the Search for
143
ANIMAL MODELS OF GENETIC BASED SKIN DISEASES
155
The Angora go Mutation Chromosome 5
165
The Asebia ab ah1 Mutations Chromosome 19
171
The Atrichosis at Mutation Chromosome 10
179
The BarePatches Bpa Mutation Chromosome X
193
The Caracul Ca and Cad Mutations Chromosome 15
211
The CurlyWhiskers cw Mutation Chromosome 9
231
The Nude nu and Streaker nuar Mutations Chromosome 11
379
The Repeated Epilation Er Mutation Chromosome 4
399
The Satin sa Mutation Chromosome 13
413
The Shaven Sha Mutation Chromosome 15
431
The SparseCoat spc Mutation Chromosome 14
447
The TightSkin Tsk Mutation Chromosome 2
463
Introduction
483
Alopecia Areata in Aging C3HHeJ Mice
499
Index
533
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