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The Adam Family of Proteases

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Nigel M. Hooper, Uwe Lendeckel
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Springer-Verlag New York Incorporated, Jan 1, 2005 - Science - 344 pages
The ADAM Family of Proteases provide the first comprehensive review of the roles of ADAMs and the related ADAMTS proteases in biology and disease. Although a few members of the ADAM (a disintegrin and metalloprotease) family have been known for some time, it is only in recent years through advances in genome sequencing that the large size of this family of zinc metalloproteases has become apparent. These proteins have multiple domains including a protease domain and a disintegrin domain. A branch of the family, called ADAMTS, also have thrombospondin-like motifs. The role of ADAMs and ADAMTS members in a diversity of biological processes is gradually coming to light. For example, some ADAMs have critical roles in the ectodomain shedding of membrane proteins including tumour necrosis factor-a, the cell signalling molecule Notch and the Alzheimerbs amyloid precursor protein. Other ADAM and ADAMTS family members have key roles to play in sperm function and fertility, collagen processing, development, cardiac hypertrophy and arthritis.

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About the author (2005)

Nigel Hooper is Professor of Biochemistry in the School ofBiochemistry and Molecular Biology at the University of Leeds, UK. Hereceived his Ph.D in 1984 from the University of Leeds with a thesison the "Metabolism of Neuropeptides by Cell-surface Peptidases" whichstimulated his interest in proteases and paved the way for much of hissubsequent research. He currently co-leads the Proteolysis ResearchGroup at Leeds and among other topics, continues to study thestructure and function of several cell-surface proteases, with aparticular interest in their mode of attachment to the membrane. Hehas published over 90 research papers, edited 4 books and co-authoredthe widely acclaimed undergraduate textbook Instant NotesBiochemistry.

Uwe Lendeckel is a Reader at the Institute of Experimental InternalMedicine at the Otto-von-Guericke University of Magdeburg, Germany.After his study of pharmacology and toxicology he received his Ph.D inbiochemistry in 1990 from the Ernst-Moritz-Arndt University ofGreifswald. His thesis on the "expression of the pro-opiomelanocortingene in rat Islets of Langerhans and other tissues" stimulated hisinterest in the neuro-immunological cross-talk and the regulatoryroles of cell surface proteases therein. In 1989 he joined theectopeptidase research group at the University of Magdeburg and sincethen continues to study regulation of expression and the function of Tcell ectopeptidases in the normal and pathological immune response,with special focus on the membrane alanyl-aminopeptidase. He haspublished over 40 research papers.

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