Statistical Aspects of the Design and Analysis of Clinical TrialsFully updated, this revised edition describes the statistical aspects of both the design and analysis of trials, with particular emphasis on the more recent methods of analysis.About 8000 clinical trials are undertaken annually in all areas of medicine, from the treatment of acne to the prevention of cancer. |
Contents
An Introduction to Clinical Trials | 1 |
1 | 16 |
4 | 33 |
Outcome | 37 |
Basic Analyses of Clinical Trials | 69 |
5 | 96 |
Simple Approaches to the Analysis | 107 |
LONGITUDINAL DATA | 117 |
Other editions - View all
Statistical Aspects of the Design and Analysis of Clinical Trials Brian Everitt,Andrew Pickles Limited preview - 2004 |
Common terms and phrases
allocation ANCOVA approach Aspirin assessment assumed assumption Bayesian binary Biometrika censored Chapter clinical trials clinicians compared compliance confidence interval considered correlation costs covariance matrix Cox model described Diggle dose dropout drug example fitted generalised linear models given group sequential hazard function hazard ratio included individual interim analyses involved logistic regression longitudinal data marginal model maximum likelihood mean meta-analysis methods missing data missing values multivariate myocardial infarction number of patients odds ratio oestrogen patch data outcome measures outcome variable overdispersion p-value parameter estimates placebo plot Pocock prior probability problem procedures prognostic factors proportional hazards model random effects model randomised trial regression model repeated measurements repeated observations residuals response variable robust sample score significance Spiegelhalter standard errors standard treatment Statist statisticians suggests summary measure survival data survivor function therapy tion treatment difference treatment effect treatment groups variance weights
References to this book
A Handbook of Statistical Analyses Using SPSS Sabine Landau,Brian S. Everitt No preview available - 2004 |