Schistosomiasis: The St Lucia ProjectSchistosomiasis is a disease affecting over 200 million people in developing countries. It is caused by worms that need particular species of fresh water snails for completing their life cycle, and developments in Third World countries have spread and increased the severity of the disease. Dr Jordan describes a 15 year study on St Lucia, a mountainous Caribbean Island where isolated valleys provided ideal field laboratories for comparing the effects on transmission, the advantages and disadvantages of intensive snail control, environmental improvement (providing villages with water), and chemotherapy with newly available drugs. The project was staffed by a multidisciplinary team and their intensive programme led to successful control. This book describes the investigation, fully and readably. It will be valuable to all who work in the fields of tropical medicine, parasitology, epidemiology, community and environmental health, and vital to workers on schistosomiasis control in developing countries. |
Contents
Introduction | 1 |
The island of St Lucia | 9 |
Snail intermediate hosts and schistosomiasis in | 31 |
The strategic plan and methods of investigation | 44 |
Untreated comparison areas | 71 |
Chemotherapy in control | 92 |
Control of the intermediate snail host | 116 |
Fond St Jacques | 166 |
Comparison of control strategies | 268 |
Drug trials | 289 |
Molluscicide trials | 307 |
Biological control | 327 |
Epidemiology | 340 |
Immunological studies Dr D G Colley | 379 |
Balanced incomplete block design for studying water contact | 398 |
Identification of freshwater fish killed by molluscicide | 404 |
Common terms and phrases
adults age groups amongst banana drains Barnish C/R ratio Calypso Calypso area cercariae chemical chemotherapy chemotherapy campaigns comparison area contamination cost Cul de Sac dose egg excretion egg output endemic exam exposure faeces Fond St Fond St Jacques found infected g/m² geometric mean glabrata granifera habitats hepatosplenomegaly high transmission areas hycanthone incidence increased index sites infected snails infection rates intensity of infection investigated island laboratory latrines laundry and shower liver low transmission areas mansoni infection Marquis valley marsh mg/kg miracidia molluscicide months niclosamide oxamniquine Paix Bouche parasitological patients praziquantel pre-control Prentice prevalence and intensity programme rainfall Ravine reduced Richefond valley south river Roseau valley routine focal Sac valley samples schistosomal schistosomiasis sentinel snail shower units shown in Table slow-release snail infection snail populations Soufriere St Lucia standpipe stool examination stream Sturrock survey TBTO treated treatment villages water contact
Popular passages
Page 422 - Asofsky, R., 1982. Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B-lymphocytes or complement.
Page 407 - KS WARREN. 1964. Mild prolonged schistosomiasis in mice: alterations in host response with time and the development of portal fibrosis. Trans. Roy. Soc. Trop. Med. Hyg. 58: 53-57.