Metabolism at a Glance

Front Cover
John Wiley & Sons, May 30, 2013 - Medical - 128 pages
Metabolism at a Glance is a complete review course ofmetabolism in health and disease and offers a unique approach tothe study of this difficult discipline.

Metabolism is a complicated subject involving complex moleculesand interrelated pathways. These metabolic pathways are usuallytaught separately with the result that the student develops adetailed but compartmentalised approach to metabolism andfrequently fails to see the overall picture and its physiologicalsignificance.

Using the at a Glance format, the book takes the student througha complete course in intermediary metabolism in an integratedmanner. The same chart is repeated throughout the book with theindividual pathway under study highlighted.

The book is an ideal text for introductory biochemistry coursesand has established itself as an enormously popular book amongstlecturers and students alike. This third edition is fully updatedand includes five new chapters to mirror those topics currentlytaught at undergraduate level:

1. Metabolic Channelling

2. Glucose homeostasis and Reye's Disease

3. Pentose phosphate pathway and the prodcution of NADPH

4. Tryptophan metabolism in health and disease

5. Tyrosine metabolism in health and disease

 

Selected pages

Contents

Foreword
8
Preface
9
1 Introduction to metabolic pathways
10
ATP the molecule that powers metabolism
12
mitochondrial respiratory chain
14
the malateaspartate shuttle and the glycerol phosphate shuttle
16
5 Metabolism of glucose to provide energy
18
6 Metabolism of one molecule of glucose yields 31 or should it be 38? molecules of ATP
20
29 ßOxidation of unsaturated fatty acids
66
30 Peroxisomal ßoxidation
68
31 Elongation and desaturation of fatty acids
70
32 Cholesterol bile acids and the steroid hormones
72
the urea cycle
74
enzymes are organized to enable channelling of metabolic intermediates 76
76
35 Biosynthesis of the nonessential amino acids
78
36 Catabolism of amino acids I
80

7 Metabolism of glucose to glycogen
22
8 Anaerobic metabolism of glucose and glycogen to yield energy as ATP
24
9 23Bisphosphoglycerate 23BPG and the red blood cell
26
10 Metabolism of glucose to fat triacylglycerol
28
11 Metabolism of glucose to fatty acids and triacylglycerol
30
the production of NADPH and reduced glutathione 32
32
13 The pyruvatemalate cycle and the production of NADPH
34
14 Mammals cannot synthesize glucose from fatty acids
36
15 Metabolism of triacylglycerol to provide energy as ATP
38
16 Glycogen metabolism I
40
17 Glycogen metabolism II
42
regulation of glycogen breakdown
44
regulation of glycogen synthesis
46
overview exemplified by glycolysis in cardiac muscle
48
21 Glycolysis and the pentose phosphate pathway collaborate in liver to make fat
50
biochemistry of sport and exercise
52
23 Regulation of gluconeogenesis
54
24 Regulation of Krebs cycle
56
mobilization of fatty acids from storage in adipose tissu
58
26 Fatty acid oxidation and the carnitine shuttle
60
27 The ketone bodies
62
28 Ketone body utilization
64
37 Catabolism of amino acids II
82
38 Metabolism of amino acids to glucose in starvation and during the period immediately after refeeding
84
39 Metabolism of protein to fat
86
40 Disorders of amino acid metabolism
88
41 Phenylalanine and tyrosine metabolism
90
the biosynthesis of NAD+ serotonin and melatonin
92
purine biosynthesis
94
pyrimidine biosynthesis
96
45 Porphyrin metabolism haem and the bile pigments
98
46 Metabolism of ethanol
100
47 Sorbitol galactitol glucuronate and xylitol
102
48 Fructose metabolis
104
49 Metabolic pathways in fasting liver and their disorder in Reyes syndrome
106
insulinstimulated glucose uptake into cells and glycogen synthesis signal transduction
108
metabolic changes in Type 1 diabetes
110
Type 1 diabetes Type 2 diabetes MODY and pancreatic ßcell metabolism
112
Type 2 diabetes and insulin resistance in muscle
114
Type 2 diabetes and insulin resistance in adipose tissue
116
Type 2 diabetes and insulin resistance in liver
118
Index
121
Copyright

Other editions - View all

Metabolism at a Glance
J. G. Salway
Limited preview - 2016
Metabolism at a Glance
J. G. Salway
Limited preview - 2017
Metabolism at a Glance
J. G. Salway
No preview available - 1994
View all »

Common terms and phrases

2-phosphoglycerate 3-oxidation a-ketoglutarate acetoacetate acetyl CoA active acyl CoA adipocytes adipose tissue alanine amino acids aminotransferase aspartate B-oxidation biosynthesis blood c-coo carboxylase carnitine catabolism catalysed causes cells Chapter Chart CHOH chopo citrate CoA dehydrogenase CoASH concentration cytosol deficiency Diagram enzyme FADH FADH2 fatty acid synthesis glucokinase gluconeogenesis glucose 6-phosphate glucose transporters GLUT4 glutamate glutamine glyceraldehyde glycine glycogen synthesis glycogenolysis glycolysis H OH HCOH HoNoH hormones inactivated inactive inhibited ketogenesis ketone bodies Krebs cycle L-3-hydroxyacyl CoA lactate liver malate malonyl metabolism mitochondrion molecules NAD+ NADH NADH+H NADP NADPH OH H oxaloacetate oxidation oxygen palmitate palmitoyl CoA pentose phosphate pathway peroxisomal phosphatase phosphofructokinase-1 phosphorylation precursor produced protein kinase protein phosphatase-1 protons purine pyruvate dehydrogenase reaction reductase regulation respiratory chain serine shuttle stimulates substrate succinate succinyl CoA synthase synthetase thiolase translocation triacylglycerol tryptophan Type 2 diabetes tyrosine urea cycle

About the author (2013)

J. G. Salway is the author of Metabolism at a Glance, 3rd Edition, published by Wiley.

Bibliographic information

TitleMetabolism at a Glance
At a Glance
AuthorJ. G. Salway
Edition3
PublisherJohn Wiley & Sons, 2013
ISBN1118682076, 9781118682074
Length128 pages
Subjects › 

Medical / Endocrinology & Metabolism
Medical / General
  
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