Contemporary Drug SynthesisAn integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume:
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Contents
Chapter 1 Antithrombotics Ticlopidine Ticlid and Clopidogrel Plavix | 1 |
Chapter 2 Antiinflammatory Cyclooxygenase2 Selective Inhibitors Celecoxib Celebrex and Rofecoxib Vioxx | 11 |
Chapter 3 H+K+ATPase Inhibitors Esomeprazole Nexium | 21 |
Chapter 4 Proteintyrosine Kinase Inhibitors Imatinib Gleevec and Gefitinib Iressa | 29 |
Chapter 5 Nonsedating Antihistamines | 39 |
Chapter 6 Cosmeceuticals Isotretinoin Accutane Tazarotene Tazorac Minoxidil Rogaine and Finasteride Propecia | 55 |
Chapter 7 Antibacterials Ciprofloxacin Cipro and Linezolid Zyvox | 75 |
Chapter 8 Atypical Antipsychotics | 89 |
Chapter 9 Atorvastatin Calcium Lipitor | 113 |
Chapter 10 Antidepressants | 125 |
Chapter 11 Antiobesity Orlistat Xenical | 149 |
Chapter 12 Triptans for Migraine | 161 |
Chapter 13 PDE 5 Inhibitors for Erectile Dysfunction Sildenafil Viagra Vardenafil Levitra and Tadalafil Cialis | 189 |
Chapter 14 Antiasthmatics | 201 |
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Other editions - View all
Contemporary Drug Synthesis Jie Jack Li,Douglas S. Johnson,Drago R. Sliskovic,Bruce D. Roth No preview available - 2004 |
Common terms and phrases
acetic acetone acid AcOH acylation afford alcohol alkylation almotriptan amine antibacterials antipsychotics aqueous HCl aripiprazole asymmetric atorvastatin bromide catalyst celecoxib cetirizine CH3CN Chem chiral chloride ciprofloxacin clopidogrel CO₂Et CO₂H CO₂Me Compound condensation CONHPh cyclization desloratadine diastereomers Drugs Fut eletriptan enantiomerically enantiomers enantioselective ester ethanol EtOAc EtOH fexofenadine finasteride Fischer indole fluoxetine fluticasone Friedel-Crafts frovatriptan gave give H₂ H₂N H₂O hydrazine hydrochloride hydrogenation hydrolysis inhibition inhibitor intermediate isotretinoin kinase Launched LIAIH4 linezolid loratadine MeHN MeOH metabolism metabolite methyl minoxidil mixture n-BuLi NaBH4 NaOH naratriptan nitro NMe2 olanzapine orlistat oxidation paroxetine patent Pd/C PDE5 Pfizer pharmacokinetics piperazine presence protein quetiapine quinolone racemic reaction receptors recrystallization reduction reflux risperidone rizatriptan rofecoxib route salmeterol salt serotonin shown in Scheme side-effects sildenafil sodium subsequently sumatriptan synthesis tazarotene Tetrahedron Lett ticlopidine toluene Trade Name treatment USAN vardenafil yield ziprasidone zolmitriptan