GlucocorticoidsNicolas J. Goulding, Rod J. Flower The development of glucocorticoids as therapeutic agents.- Glucocorticoid biology - a molecular maze and clinical challenge..- Glucocorticoid biology - a historical perspective.- The development of synthetic glucocorticoids.- Molecular mechanisms of glucocorticoid action.- The glucocorticoid receptor: expression, function, and regulation of glucocorticoid responsiveness.- Molecular and cellular aspects of cytokine regulation by glucocorticoids.- Current perspectives in glucocorticoid biology.- Glucocorticoids and leukocyte adhesion.- Annexin I as a mediator of glucocorticoid action.- Glucocorticoids and the HPA axis.- The role of 11?-hydroxy steroid dehydrogenase in regulating glucocorticoid action..- Glucocorticoids in contemporary clinical practice.- Glucocorticoids and asthma.- Systemic glucocorticoids in chronic arthritis.- Glucocorticoids in the control of inflammatory bowel disease. |
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11ẞ-HSD activity Acad Sci USA ACTH action of glucocorticoids adrenal cortex affinity amino acids annexin anti-inflammatory AnxA1 asthma Biol Chem budesonide cellular Cidlowski Clin clinical cocorticoid coids complex corticoid corticosteroid cortisol cytokines dexamethasone disease domain dose drugs effect of GC effects of glucocorticoids endothelial enzyme exon Flower RJ function gene expression gene transcription glucocorti glucocorticoid receptor glucocorticoid resistance glucose GR gene HPA axis human hydrocortisone immune Immunol immunosuppressive increase induced inflammation inflammatory inhibition inhibitory interaction interleukin involved kinase leukocyte levels ligand lipocortin lymphocytes mechanisms mediated membrane metabolism methylprednisolone mineralocorticoid receptor modulation Mol Endocrinol molecular monocytes mRNA Natl Acad Sci neutrophils nuclear pathways patients peptide phosphorylation physiological pituitary potential prednisolone prednisone Proc Natl Acad promoter protein regulation release rheumatoid arthritis role side-effects specific steroid hormones stress studies synthesis synthetic glucocorticoids T-cells therapy tion tissues transcription factors transcriptional activity treatment up-regulation vitro vivo