Skin Barrier

Front Cover
Peter M. Elias, Kenneth R. Feingold
CRC Press, Sep 22, 2005 - Medical - 632 pages
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A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatitis, psoriasis, and ichthyosis.
  

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Contents

Definitions and Broad Concepts
1
Integrative Aspects
5
3 A Brief History of How the Dead Stratum Corneum Became Alive
15
From Saran Wrap to Biosensor
25
5 Biochemistry of Human Stratum Corneum Lipids
33
Function Origins and Therapeutic Applications
43
7 Structure of the Skin Barrier
65
8 Cornified Envelope and CorneocyteLipid Envelope
97
19 The Role of the Primary Cytokines TNF IL1 and IL6 in Permeability Barrier Homeostasis
305
Epidermal Liposensors
319
21 Permeability Barrier Homeostasis
337
22 Cutaneous Barriers in Defense Against Microbial Invasion
363
23 The Epidermal Antioxidant Barrier
379
24 Sources and Role of Stratum Corneum Hydration
399
25 Vitamin D and the Epidermis
427
26 Diseases That Affect Barrier Function
447

9 Profilaggrin and the Fused S100 Family of CalciumBinding Proteins
111
10 The Role of Keratins in Epithelial Homeostasis
141
Pivotal Actors in the Stratum Corneum Cohesion and Desquamation
171
Role of Tight Junctions
191
13 What Makes a Good Barrier? Adaptive Features of Vertebrate Integument
211
Measurement Origins and Functions
223
The Final Steps in Barrier Formation
231
16 The Epidermal Lamellar Body as a Multifunctional Secretory Organelle
261
17 Skin Structural Development
273
18 Epidermal Calcium Gradient and the Permeability Barrier
289
27 Pathogenesis of the Barrier Abnormalities in Disorders of Cornification
469
28 Pathogenesis of Desquamation and Permeability Barrier Abnormalities in RXLI
511
29 Prevention and Repair of Barrier Disruption in Occupational Dermatology
519
Basis for Functional Abnormalities
535
The Psychosensory Interface
553
32 The Stratum Corneum of the Epidermis in Atopic Dermatitis
569
Fixing the BarrierTheory and Rational Deployment
591
Index
601
Back cover
613
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