The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs

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John Wiley & Sons, Jan 11, 2011 - Medical - 504 pages
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Based on his profound knowledge of past and present paradigms in the development of medicines, the author takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form.
The book is beautifully illustrated, containing historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details.
For anyone with a more than superficial interest in the science of drugs: instructive and enjoyable for a broad audience of students, instructors and professionals in pharmacy, the pharmaceutical chemistry and related fields.
  

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Contents

Evolution of Drug Discovery
1
The First Synthetic Drugs and the Birth of Chemotherapy
23
From Traditional Medicines to Modern Drugs Enrique Ravina
53
Drugs from Natural Products
107
Warfarin and Acenocoumarol
146
Rationalizing the Drug Discovery Process
313
StructureBased Drug Discovery
405
7 Biopharmaceuticals
441
Concluding Remarks
461
Index
467
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About the author (2011)

Enrique Ravina holds the chair for Pharmaceutical Organic Chemistry at the University of Santiago de Compostela (Spain). He was trained as a organic chemist and has a lifetime of experience in pharmaceutical chemistry, most prominently in the area of antipsychotic and cardiovascular drugs. He is a member of the Spanish Royal Academy of Pharmacy, a founding member of the Spanish Society of Medicinal Chemistry, and a member of the American Chemical Society. In 2008, he has published a highly acclaimed book on the history of drugs and their discovery in Spain (published in Spanish language).

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