Genes & Signals

Front Cover
CSHL Press, 2002 - Science - 192 pages
0 Reviews
Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Lessons from Bacteria
11
THE BACTERIOPHAGE X
26
Antitermination Nand Q
38
Phage T4 Late Genes
47
FOOTNOTES
53
A Singlecelled Eukaryote
59
HOW Gal4 WORKS
67
Activator Bypass Experiments
81
BIBLIOGRAPHY
110
RECRUITMENT
116
DETECTING AND TRANSMITTING PHYSIOLOGICAL SIGNALS
123
ACTION AT A DISTANCE
129
COMPARTMENTALIZATION
135
Enzyme Specificity and Regulation
143
INTERIM SUMMARY AND EXTENSIONS
156
FOOTNOTES
167

SIGNAL INTEGRATION AND COMBINATORIAL CONTROL
92
Variegation Visualized
99
Topogenic Sequences
183
Copyright

Other editions - View all

Common terms and phrases

Popular passages

Page 173 - The difficulty lies, not in the new ideas, but in escaping from the old ones, which ramify, for those brought up as most of us have been, into every corner of our minds.
Page 142 - Bell, AC, and Felsenfeld, G. (1999). Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 9, 191-198.
Page 57 - Salas M. 1998. Transcription activation and repression by interaction of a regulator with the a subunit of RNA polymerase: The model of phage <(>29 protein p4.
Page 56 - Gaal. 2000. UPs and downs in bacterial transcription initiation: the role of the a subunit of RNA polymerase in promoter recognition. Mol. Microbiol. 37:687-695. 31. Griffith, KL, IM Shah, TE Myers, MC O'Neill, and RE Wolf, Jr. 2002. Evidence for "pre-recruitment...
Page 170 - Patton, EE, Willems, AR, and Tyers, M. (1998). Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. Trends Genet. 14, 236-243.
Page 57 - Rombel, I., North, A., Hwang, I., Wyman, C. and Kustu, S. (1998) Cold Spring Harbor Symp Quant Biol. 63, 157-166.

References to this book

All Book Search results &raquo;

About the author (2002)

Alexander Gann (the Lita Annenberg Hazen Dean-Elect) is a member of the faculty of the Watson School of Biological Sciences.

Bibliographic information