Genes & Signals
Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
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THE BACTERIOPHAGE X
Antitermination Nand Q
Phage T4 Late Genes
A Singlecelled Eukaryote
HOW Gal4 WORKS
Activator Bypass Experiments
DETECTING AND TRANSMITTING PHYSIOLOGICAL SIGNALS
ACTION AT A DISTANCE
Enzyme Specificity and Regulation
INTERIM SUMMARY AND EXTENSIONS
SIGNAL INTEGRATION AND COMBINATORIAL CONTROL
absence acetylation acidic activators acti activates transcription activating region activator bypass experiments allosteric bacteria bind cooperatively bind DNA binding sites Biol bound cell cycle Chapter chromosome Cold Spring Harbor coli complex components concentration cooperative binding Curr cyclin cytokine deletion dimer DNA-binding domain DNA-binding proteins Drosophila effect encoding enhanceosome enhancer enzyme eukaryotes example F-box protein factors function GAL1 Gal4 galactose Gcn5 gene activation gene expression gene regulation Genet HDAC higher eukaryotes histone induces interaction kinase Lac repressor lactose loop lysogen lytic mammalian mechanism mediator merase mutants NtrC nucleosome nucleosome modifiers nucleus Opin P-TEFb phage phosphorylation poly promoter protein called protein-protein proteins bind Ptashne receptor regulated recruitment repression repressor binds residues RNA polymerase RNA polymerase II sequence SH2 domain silencing Sir2 specific splicing STAT substrate subunit Swi/Snf switch target teins telomere tethered tion transcribed transcriptional activators transcriptional machinery tyrosine ubiquitylating upstream vitro yeast
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