Genes & Signals
Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
What people are saying - Write a review
We haven't found any reviews in the usual places.
THE BACTERIOPHAGE A
Making an Efficient Switch
Antitermination N and Q
Phage T4 Late Genes
A Singlecelled Eukaryote
HOW GalA WORKS
DETECTING AND TRANSMITTING PHYSIOLOGICAL SIGNALS
ACTION AT A DISTANCE
Enzyme Specificity and Regulation
INTERIM SUMMARY AND EXTENSIONS
Activator Bypass Experiments
SIGNAL INTEGRATION AND COMBINATORIAL CONTROL
absence acetylation acidic activators acti activates transcription activating region activator bypass experiments affinity allosteric bacteria bind cooperatively bind DNA binding sites Biol cell cycle chromatin chromosome Cold Spring Harbor coli complex components concentration cooperative binding Curr cyclin cytokine deletion dimer DNA-binding domain DNA-binding proteins Drosophila effect encoding enhanceosome enhancer enzyme eukaryotes example F-box protein factors function Gal+ GalA galactose Gcn5 gene activation gene expression gene regulation Genet HDACs higher eukaryotes histone induces kinase lac genes Lac repressor lactose loop lytic mammalian mechanism mediator merase Migl mutants Ntro nucleosome nucleosome modifiers nucleus Opin P-TEFb phage phosphorylation poly promoter protein called proteins bind Ptashne receptor regulated recruitment repression repressor bound residues RNA polymerase RNA polymerase II sequence SH2 domain silencing Sir2 specific splicing STAT substrate subunit Swi/Snf switch target teins telomere tethered tion transcribed transcriptional activators transcriptional machinery Tup1 tyrosine ubiquitylating upstream vitro yeast
Page 175 - The difficulty lies, not in the new ideas, but in escaping from the old ones, which ramify, for those brought up as most of us have been, into every corner of our minds.
Page 144 - Bell, AC, and Felsenfeld, G. (1999). Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 9, 191-198.
Page 143 - Taniguchi, T., Ogasawara, K., Takaoka, A. and Tanaka, N. (2001). IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19. 623-655.
Page 143 - Glass, CK, and Rosenfeld, MG (2000). The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev., 14, 121-141.
Page 59 - Salas M. 1998. Transcription activation and repression by interaction of a regulator with the a subunit of RNA polymerase: The model of phage <(>29 protein p4.
Page 112 - Orphanides, G., Lagrange, T., and Reinberg, D. (1996) The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-2683.
Page 58 - Gaal. 2000. UPs and downs in bacterial transcription initiation: the role of the a subunit of RNA polymerase in promoter recognition. Mol. Microbiol. 37:687-695. 31. Griffith, KL, IM Shah, TE Myers, MC O'Neill, and RE Wolf, Jr. 2002. Evidence for "pre-recruitment...
Page 112 - Epigenetic Mechanisms of Gene Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 13.
Page 59 - Rombel, I., North, A., Hwang, I., Wyman, C. and Kustu, S. (1998) Cold Spring Harbor Symp Quant Biol. 63, 157-166.