Genes & SignalsGenes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types. |
Contents
| 11 | |
THE BACTERIOPHAGE 2 | 26 |
Making an Efficient Switch | 34 |
Antitermination N and Q | 38 |
Phage T4 Late Genes | 47 |
FOOTNOTES | 53 |
A Singlecelled Eukaryote | 59 |
HOW Gal4 WORKS | 67 |
BIBLIOGRAPHY | 110 |
RECRUITMENT | 116 |
DETECTING AND TRANSMITTING PHYSIOLOGICAL SIGNALS | 123 |
ACTION AT A DISTANCE | 129 |
COMPARTMENTALIZATION | 135 |
Enzyme Specificity and Regulation | 143 |
INTERIM SUMMARY AND EXTENSIONS | 156 |
FOOTNOTES | 167 |
Activator Bypass Experiments | 81 |
SIGNAL INTEGRATION AND COMBINATORIAL CONTROL | 92 |
Variegation Visualized | 99 |
Topogenic Sequences | 183 |
143 | 187 |
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Common terms and phrases
absence acti activates transcription activating region activator bypass experiments affinity allosteric allostery bacteria bearing bind cooperatively bind DNA binding sites Biol chromosome Cold Spring Harbor coli complex components concentration cooperative binding Curr cyclin dimer DNA-binding domain DNA-binding proteins Drosophila effect encoding enhanceosome enhancer enzyme eukaryotes example F-box protein factors Figure function GAL1 Gal4 galactose Gcn5 gene activation gene expression gene regulation Genet HDACs higher eukaryotes histone induces interaction karyopherin lac genes Lac repressor lactose loop lytic mammalian MAP kinase mechanism mediator merase molecule mutant NtrC nucleosome nucleosome modifiers nucleus Opin P-TEFb phage phosphorylation poly promoter protein called protein-protein proteins bind Ptashne receptor regulated recruitment regulatory repression repressor bound residues RNA polymerase sequence SH2 domain signal transduction silencing Sir2 specific splicing STAT substrate subunit Swi/Snf switch target teins telomere tion transcribed transcriptional activators transcriptional machinery tyrosine ubiquitylating upstream vitro yeast
Popular passages
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