Percutaneous Absorption: Drugs--Cosmetics--Mechanisms--Methodology: Drugs--Cosmetics--Mechanisms--Methodology, Third Edition,

Front Cover
Robert L. Bronaugh, Howard I. Maibach
CRC Press, May 28, 1999 - Science - 986 pages
Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body.
Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research!
Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details
  • the applied biology of percutaneous penetration
  • factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure
  • in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes
  • procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue
    And presents new chapters on
  • mathematical models
  • cutaneous metabolism
  • prediction of percutaneous absorption
  • in vitro absorption methodology
  • dermal decontamination
  • concentration of chemicals in skin
  • transdermal drug delivery
  • mechanisms of absorption
  • safety evaluation of cosmetics
  • absorption of drugs and cosmetic ingredients
  • nail penetration
    Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines!
    An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.
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    Contents

    V
    3
    VII
    57
    VIII
    65
    X
    81
    XII
    107
    XIV
    117
    XVI
    133
    XVIII
    149
    LXVI
    499
    LXVIII
    515
    LXXI
    555
    LXXIII
    571
    LXXV
    587
    LXXVII
    595
    LXXVIII
    597
    LXXX
    615

    XX
    177
    XXII
    193
    XXV
    213
    XXVI
    215
    XXVIII
    229
    XXX
    235
    XXXII
    241
    XXXIV
    255
    XXXVI
    271
    XXXVIII
    283
    XL
    289
    XLII
    297
    XLIV
    315
    XLVII
    347
    XLIX
    375
    LI
    395
    LIII
    411
    LV
    427
    LVII
    451
    LIX
    463
    LXI
    475
    LXIV
    487
    LXXXII
    633
    LXXXIV
    659
    LXXXVI
    673
    LXXXVIII
    685
    XC
    717
    XCII
    733
    XCV
    741
    XCVII
    759
    XCIX
    779
    CII
    789
    CIV
    809
    CVI
    815
    CIX
    825
    CXI
    861
    CXIII
    879
    CXV
    887
    CXVII
    901
    CXIX
    915
    CXXII
    929
    CXXIV
    939
    CXXVI
    951
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