For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
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Synthesis Assembly and Processing of Viral Proteins 263
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Acad activity amino acid ASLV assay assembly avian binding Biol cellular Chem cleavage complex core Craigie cytoplasm dimer DNA polymerase DNA synthesis domain ecotropic encoded endogenous enhancer Env proteins envelope glycoprotein enzyme expression function fusion Gag proteins gene genetic genome genomic RNA glycoprotein H.E. Varmus HIV-1 RT host human immunodeficiency virus immunodeficiency virus type infected cells inhibitors integrase integration interactions isolates mediate membrane MMTV molecular molecules Moloney murine leukemia mouse mRNA murine leukemia virus mutations Natl NF-kB Nucleic Acids nucleotides oncogene packaging particles peptide polyprotein precursor primer Proc processing protease protein provirus quences receptor recombination region replication residues retroviral retroviruses reverse transcriptase RNase H role Rous sarcoma virus S.P. Goff sequences specific splicing strand transfer structure subgroup substrate T-cell target template terminal tion trans transcription factors tRNA tumor viruses viral DNA ends virions Virol Virology vitro vivo Vogt
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