The Lock and Key of Medicine: Monoclonal Antibodies and the Transformation of Healthcare

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Yale University Press, Jan 1, 2015 - Medical - 316 pages
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The untold story of monoclonal antibodies--the molecular heroes of biotechnology that revolutionized the diagnosis and treatment of more than fifty major diseases

This book is the first to tell the extraordinary yet unheralded history of monoclonal antibodies. Often referred to as Mabs, they are unfamiliar to most nonscientists, yet these microscopic protein molecules are everywhere, quietly shaping our lives and healthcare. Discovered in the mid-1970s in the laboratory where Watson and Crick had earlier unveiled the structure of DNA, Mabs have radically changed understandings of the pathways of disease. They have enabled faster, cheaper, and more accurate clinical diagnostic testing on a vast scale. And they have played a fundamental role in pharmaceutical innovation, leading to such developments as recombinant interferon and insulin, and personalized drug therapies such as Herceptin. Today Mabs constitute six of the world's top ten blockbuster drugs and make up a third of new introduced treatments.

Lara V. Marks recounts the risks and opposition that a daring handful of individuals faced while discovering and developing Mabs, and she addresses the related scientific, medical, technological, business, and social challenges that arose. She offers a saga of entrepreneurs whose persistence and creativity ultimately changed the healthcare landscape and brought untold relief to millions of patients. Even so, as Marks shows, controversies over Mabs remain, and she examines current debates over the costs and effectiveness of these innovative drugs.
 

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Contents

1 Hunting for the Elusive Magic Bullet
1
Patents Politics and Process
25
3 Breakthroughs at the Bench
47
4 The First Medical Applications
69
Early Clinical Tests
88
6 The Wild West of Antibody Commercialization
110
7 The Challenge of Monoclonal Antibody Drugs
139
A Renaissance for Mab Therapeutics
159
9 Blockbuster Mab Drugs
184
The Legacy of Monoclonal Antibodies
218
Notes
237
Glossary
293
Bibliography
301
Index
307
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About the author (2015)

Lara V. Marks is a historian of medicine. She is managing editor of the website whatisbiotechnology.org and has research affiliations with King's College London and Cambridge University. She lives in Kent, UK.

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