Molecular Biotechnology: Therapeutic Applications and StrategiesMOLECULAR BIOTECHNOLOGY Therapeutic Applications and Strategies SUNIL MAULIK and SALIL D. PATEL Recombinant DNA technology, or genetic engineering, has revolutionized our understanding of life at the molecular level-giving us a detailed picture of the living cell's functions and spawning diverse biotechnologies that use molecules, cells, tissues, and even entire organisms. This introduction to molecular biotechnology is a practical, up-to-date guide to this rapidly growing field. Based on courses taught by the authors to biotechnology professionals, Molecular Biotechnology: Therapeutic Applications and Strategies applies the principles of modern biotechnology to advances and trends in the development of therapeutic strategies and approaches to disease prevention and intervention. By focusing on select applications and strategies, this volume exemplifies the convergence of biological, chemical, and informational advances in the discovery of novel targets and drugs. This multidisciplinary approach, essential to the development of commercial therapeutic molecules, includes carefully selected real-world examples from the pharmaceutical and biotechnology industries. Specific topics covered include: * Genome Based Medicine and the Human Genome Project * Human Gene Therapy * Combinatorial Chemistry * Rational Drug Design * Reengineering the Immune System User-friendly and organized for maximum understanding, Molecular Biotechnology: Therapeutic Applications and Strategies is an excellent text/reference for biotechnology professionals, researchers, physicians, students, managers, industry analysts, and investors interested in learning more about the field of molecular biotechnology. |
Common terms and phrases
active affinity alleles allow amino acids analysis antagonists antigen atoms autoimmune binding biotechnology cancer cDNA cell surface cellular CGTTTTT chemical chemistry chromosome class II molecules cloning combinatorial libraries CoMFA complex compounds conformational Corp cystic fibrosis cytokines databases determine diabetes domain drug design effect enzyme expression fragments functional groups gene therapy Genentech genetic human genome identified immune response immune system infection inhibit inhibitors interaction intracellular isolated lead ligands linkage lymphocytes markers methods MHC molecules mice mimetic molecular diversity molecules monoclonal antibodies monomers mouse mRNA mutations NOD mice novel oligonucleotides organic pathogens pathways peptide phage display Pharmaceuticals pharmacological pharmacophore procedure protease protein QSAR receptor recombinant region replication residues result retroviral ribozymes Science screening selection sequence signal solid-phase synthesis specific strand strategies structure substituent synthesis T-cell tagged target tion tissue transcription transgenic tumor typically vector viral virus