Design and Analysis of Biomolecular Circuits: Engineering Approaches to Systems and Synthetic BiologyHeinz Koeppl, Douglas Densmore, Gianluca Setti, Mario di Bernardo The book deals with engineering aspects of the two emerging and intertwined fields of synthetic and systems biology. Both fields hold promise to revolutionize the way molecular biology research is done, the way today’s drug discovery works and the way bio-engineering is done. Both fields stress the importance of building and characterizing small bio-molecular networks in order to synthesize incrementally and understand large complex networks inside living cells. Reminiscent of computer-aided design (CAD) of electronic circuits, abstraction is believed to be the key concept to achieve this goal. It allows hiding the overwhelming complexity of cellular processes by encapsulating network parts into abstract modules. This book provides a unique perspective on how concepts and methods from CAD of electronic circuits can be leveraged to overcome complexity barrier perceived in synthetic and systems biology. |
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Design and Analysis of Biomolecular Circuits Heinz Koeppl,Douglas Densmore,Gianluca Setti No preview available - 2011 |
Common terms and phrases
acid algorithm analysis applied approach Autopoiesis autopoietic behavior binding BioBrick biochemical Bioinformatics biological systems Biomolecular Circuits cellular Chem chemical kinetics chemical reaction networks codon coli complex components computational concentration construction cycle defined denotes destination vector diffusion DNA assembly DNA sequence downstream dynamics engineering enzymes example fan-out fluorescent proteins function gene synthesis genetic GenoCAD genome graph input inside liposomes interactions IPTG Jacobian KaiC kinetics linear lipid liposomes Luisi PL MAPK martingale matrix membrane methods minimal cell modular modules molecular molecules multiple Natl Acad Sci nodes optimization oscillator output parameter pathway phosphorylation Phys polymerase Proc Natl Acad promoter properties quorum sensing retroactivity robustness sampling SBML signal transduction SLIC solution spatial specific Springer Science+Business Media standard stochastic simulation stoichiometry structure synthetic biology Syst Biol systems biology Theorem tion trajectories transcription transcription factors variables vesicles yeast