The RNA World: The Nature of Modern RNA Suggests a Prebiotic RNA World

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Raymond F. Gesteland, Thomas Cech, John F. Atkins
CSHL Press, 2006 - Science - 768 pages
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Recent studies on the activities of RNA in the cell have revolutionized our understanding of the many roles played by this molecule. The first two editions of The RNA World(1993, 1999) shed light on the pre–biotic era dominated by this versatile molecule, and provided an overview of the state of RNA research at the time.
The new third edition of The RNA Worldupdates this perspective, describing the vast array of newly discovered roles for RNA in the modern world. The updated original chapters are supplemented with new chapters on RNA–protein complexes, snRNPs and snoRNPs, telomerase RNA, RNAi, microRNAs, noncoding RNA, and many other subjects. This book is essential reading for anyone interested in the biology of nucleic acids and gene regulation and a valuable resource for teaching these concepts.

 

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Contents

The History Chemistry and Geobiology behind RNA
1
2 Progress toward Understanding the Origin of the RNA World
23
Genetic Polymers Inside Membrane Vesicles
57
4 Riboswitches and the RNA World
89
Relics of an RNA World?
109
06_RNA_Worldqxd
133
7 RNA Lipids and Membranes
207
From the RNA World to the Theater of Proteins
227
Knotting Ventured Knotting Gained
437
Ribozymes That Splice RNA and Invade DNA
469
Troublemakers Saboteurs Benefactors Ancestors
507
19 The Biology of Short RNAs
535
20 Versatile Roles of Small RNA Regulators in Bacteria
567
21 Large Noncoding RNAs in Mammalian Gene Dosage Regulation
595
22 Predicting RNA Secondary Structure
631
23 A Modular and Hierarchical Approach for AllAtom RNA Modeling
659

9 The Roles of RNA in the Synthesis of Protein
257
10 Evolution of Ribosomes and Translation from an RNA World
287
11 The RNP World
309
12 The EverGrowing World of Small Nuclear Ribonucleoproteins
327
13 Spliceosome Structure and Function
369
14 Uridine InsertionDeletion RNA Editing as a Paradigm for Sitespecific Modifications of RNA Molecules
401
15 Telomerase RNA
419
24 Automated In Vitro Selection and Microarray Applications for Functional RNA Sequences
683
25 RNA Folding Unfolding and Dynamics One Moleculeat a Time
721
26_RNA_World_Append
747
RNA World 3e Index
753
RNA World_3e back cover
769
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