The Enzymes: Protein Methyltransferases
Fuyuhiko Tamanoi, Steven G. Clarke
Elsevier, Sep 21, 2011 - Science - 592 pages
Protein methylation has recently emerged as one of the most exciting areas of study on posttranslational modification. A large family of protein methyltransferases has been identified and their structural properties have been characterized. These studies have provided novel insights into how methylation regulates a variety of biological functions including DNA and RNA metabolism, protein synthesis and signal transduction. Methylation also plays important roles in aging. This volume is intended to capture these recent developments concerning protein methyltransferases.
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Part III Biological Regulation by Protein Methyl Ester Formation
Part IV Recognition of Damaged Proteins in Aging by Protein Methyltransferases
Part V Modification of Proteins by Methylation of Glutamine and Asparagine Residues
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Acad Sci USA AdoHcy AdoMet amino acid arginine arginine methylation bacterial binding Biochem Biophys Biochemistry Biol Chem C-terminal CaaX calmodulin carboxyl methylation carboxyl methyltransferase CARM1 catalytic cellular chemotaxis CheR chromatin Clarke coactivator cofactor complex conserved cytochrome cytoplasmic demethylation dimer Drosophila enzymatic enzyme Escherichia coli factor Figure function gene genome histone H3 histone methylation histone methyltransferase hnRNP human Icmt identified inhibition inhibitor interaction isoAsp kinase LSD1 lysine mammalian MCPs mechanism membrane methyl group methyl-accepting mice modification Mol Biol Mol Cell Biol molecular motif MTase mutations Natl Acad Sci nuclear PAD4 pathway peptide PKMTs polypeptide posttranslational modification PP2A PP2AC PRMT PRMT1 PRMT3 PRMT5 Proc Natl Acad protein arginine methyltransferase protein carboxyl protein methylation protein methyltransferase Ras proteins reaction regulation residues ribosomal protein role Rubisco Rubisco LSMT Saccharomyces cerevisiae sequence SET domain signaling studies substrate subunit suggesting target transcription vitro vivo yeast Zhang