Handbook of Mouse Mutations with Skin and Hair Abnormalities: Animal Models and Biomedical ToolsHandbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects. The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system. |
Contents
Hair Follicle Stem Cells | 30 |
The Mouse Skin as a Model for Chemical Carcinogenesis | 39 |
Viral Induced Skin Tumors in Mice | 47 |
Hair Types and Subtypes in the Laboratory Mouse | 57 |
Growth Factors and Cutaneous Pathology | 69 |
Transgenic Mice with Cytokine Mutations Affecting the Skin | 81 |
Epidermal Keratins | 95 |
Hair Follicle Keratins | 105 |
The Downless dl and Sleek Disk Mutations Chromosome 10 | 245 |
The Flaky Tail ft Mutation Chromosome 3 | 269 |
The Greasy Gs Mutation Chromosome X | 285 |
The Hair Patches Hpt Mutation Chromosome 4 | 313 |
The Ichthyosis ic Mutation Chromosome 1 | 327 |
The Lustrous lt Mutation Chromosome 11 | 343 |
The mammalian hair cycle is a fascinating example of tissue development and remodeling that | 345 |
Mottled Mo Blotchy Moblo Brindled Mob | 359 |
Keratinocyte Cultures as Models for Dermatological Disease | 117 |
Mouse Mutations with Endocrine Functional Consequences | 129 |
the Search for | 143 |
ANIMAL MODELS OF GENETIC BASED SKIN DISEASES | 155 |
The Angora go Mutation Chromosome 5 | 165 |
The Asebia ab ab Mutations Chromosome 19 | 171 |
The Atrichosis at Mutation Chromosome 10 | 179 |
The BarePatches Bpa Mutation Chromosome X | 193 |
The Caracul Ca and Cad Mutations Chromosome 15 | 211 |
The CurlyWhiskers cw Mutation Chromosome 9 | 231 |
The Nude nu and Streaker nustr Mutations Chromosome 11 | 379 |
The Repeated Epilation Er Mutation Chromosome 4 | 399 |
The Satin sa Mutation Chromosome 13 | 413 |
The Shaven Sha Mutation Chromosome 15 | 431 |
The SparseCoat spc Mutation Chromosome 14 | 447 |
The TightSkin Tsk Mutation Chromosome 2 | 463 |
Introduction | 483 |
Alopecia Areata in Aging C3HHeJ Mice | 499 |
533 | |
Other editions - View all
Common terms and phrases
Abnormal Abnormal Abnormal allele alopecia areata anagen ANALOGOUS ANIMAL DISEASES ANALOGOUS HUMAN DISEASE animal model autosomal recessive AVAILABILITY OF MICE background BIOCHEMICAL ABNORMALITIES Biol carcinogenesis centimorgans collagen CRC Press crinkled culture cutaneous days of age defect deficiency Dermatol dermis differentiation downless effects Embryo epidermal epithelial expression flaky skin follicular fsn/fsn function genetic GROSS LESIONS growth factor hair cycle hair follicles hair growth hair shaft hairless mouse homozygous house mouse ichthyosis immunodeficiency Immunological and Biochemical inbred strain Invest Jackson Laboratory keratin keratinocytes Laboratory Mouse littermate controls locus melanocytes MICROSCOPIC LESIONS motheaten mouse Chromosome mouse mutation Mouse News Lett mouse skin mutant genes mutant mice normal nude mice outer root sheath papillomas Pathol pelage pelage hairs phenotype pigment proteins psoriasis receptor rhino scurfy sebaceous glands severe combined immunodeficiency Shultz spontaneously stem cells studies syndrome tabby tail tight-skin tissue transgenic transgenic mice tumor vibrissae vitiligo vitro