Mechanisms of TranscriptionComplex macromolecular machinery is responsible for gene-specific and cell-type selective patterns of gene expression. How it works is being revealed by increasingly sophisticated molecular dissection of prokaryotic and eukaryotic cells. This volume reviews the results and conclusions of recent studies in gene transcription. It covers events ranging from activation, through promoter recognition, repression, chromosome structure, chromatin remodelling, initiation and elongation, and the regulation of stopping and starting. |
Contents
| 1 | |
| 21 | |
| 41 | |
| 63 | |
Past Present and Future D Reinberg | 83 |
Ten Years of TFIIH F Coin and J M Egly | 105 |
The Architecture of Its DNA Complex and Its Roles in Initiation | 121 |
The Functional and Regulatory Roles of Sigma Factors in Transcription C A Gross C Chan | 141 |
Gene Regulation by the Yeast Ssn6Tup1 Corepressor M Wahi K Komachi | 447 |
In Vivo Functions of Histone AcetylationDeacetylation in Tuplp Repression and Gen5p | 459 |
Chromosome Structure and Transcription | 469 |
Regulation of Transcription by Multisubunit Complexes That Alter Nucleosome Structure | 483 |
TBPassociated Factors in the PCAF Histone Acetylase Complex T Kotani X Zhang | 493 |
Insights into Substrate Specificity | 501 |
The Establishment of Active Chromatin Domains A Bell J Boyes J Chung M Pikaart | 509 |
Nuclear Matrix Attachment Regions Confer Longrange Function upon the Immunoglobulin | 515 |
The Bacterial Enhancerbinding Protein NtrC as a Molecular Machine I Rombel A North | 157 |
Use of Artificial Activators to Define a Role for ProteinProtein and ProteinDNA Contacts | 173 |
Cofactor Requirements for Transcriptional Activation by Sp1 A M Näär S Ryu and R Tjian | 189 |
Functional Analysis of TFIID Components W C Shen L M Apone C M A Virbasius | 219 |
Functional and Structural Analysis of the Subunits of Human Transcription Factor TFIID | 233 |
Cooperative Assembly of RNA Polymerase II Transcription Complexes K Ellwood T Chi | 253 |
Structural Studies of Escherichia coli RNA Polymerase S A Darst A Polyakov C Richter | 269 |
The Transition from Initiation to Elongation by RNA Polymerase II D S Luse | 289 |
RNA Polymerase II Thirty Years Later N A Woychik | 311 |
Structure and Mechanism in Transcriptional Antitermination by the Bacteriophage λ N Protein | 327 |
Promoterassociated Pausing in Promoter Architecture and Postinitiation Transcriptional | 347 |
RNA Polymerase II Elongation Control J Peng M Liu J Marion Y Zhu and D H Price | 365 |
A Paradigm for Eukaryotic Gene | 381 |
A General Mechanism for Regulated Repression | 401 |
The Mad Protein Family Links Transcriptional Repression to Cell Differentiation | 423 |
Remodeling Chromatin | 525 |
A Model for Chromatin Remodeling by the SWISNF Family G R Schnitzler S Sif | 535 |
Dissection of a Chromatin Remodeling Cycle C L Peterson | 545 |
Past Present and Future | 553 |
Specificity of ATPdependent Chromatin Remodeling at the Yeast PHO5 Promoter | 563 |
Role of Chromatin Structure and Distal Enhancers in Tissuespecific Transcriptional | 569 |
Regulatory Complexes and Pathways | 577 |
Signals and Surfaces K R Yamamoto | 587 |
Mechanisms of Combinatorial | 599 |
Structure and Function of the Interferonẞ Enhanceosome T Maniatis J V Falvo T H Kim | 609 |
Autoinhibition as a Transcriptional Regulatory Mechanism B J Graves D O Cowley | 621 |
Phosphorylation CBP and a Novel | 631 |
Regulation of SRF Activity by Rho Family GTPases R Treisman A S Alberts and E Sahai | 643 |
Three Decades after Sigma R Losick | 653 |
Author Index | 667 |
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Common terms and phrases
Acad activation domain amino acids amino-terminal assays assembly basal transcription binding Biochem Biol Biology carboxy-terminal Cell cerevisiae Chem chromatin coactivator cofactors Cold Spring Harbor coli RNA polymerase components containing core promoter Dept DNA-binding downstream Drosophila elongation complexes EMBO enzyme Escherichia coli eukaryotic function Gal4 Genes Dev genetic histone acetylation histone acetyltransferase histone deacetylase histone H3 holoenzyme homolog human interaction kinase lanes mediated merase Molecular moter mutations Natl NtrC nuclear nucleosome nucleotides open complex P-TEFb paused PCAF phosphorylation plex pol II preinitiation complex Proc protein purified recruitment region regulation Reinberg repression repressor residues RNA poly RNA polymerase II RNAP RNAPII Roeder R.G. role scription sequence sigma specific structure Struhl subunit SWI/SNF TAFS target TATA box TATA element template TFIIA TFIIB TFIID TFIIH tion Tjian tran transcription factor transcription initiation transcriptional activation upstream vitro vivo wild-type yeast
Popular passages
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Page 52 - This work was supported by grants from the National Institutes of Health and the National Science Foundation.
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