Human Evolutionary Genetics

Front Cover
Garland Science, Jun 25, 2013 - Medical - 650 pages
Human Evolutionary Genetics is a groundbreaking text which for the first time brings together molecular genetics and genomics to the study of the origins and movements of human populations. Starting with an overview of molecular genomics for the non-specialist (which can be a useful review for those with a more genetic background), the book shows h
 

Contents

AN INTRODUCTION TO HUMAN EVOLUTIONARY GENETICS
1
ORGANIZATION AND INHERITANCE OF THE HUMAN GENOME
17
HUMAN GENOME VARIATION
43
FINDING AND ASSAYING GENOME DIVERSITY
95
PROCESSES SHAPING DIVERSITY
133
MAKING INFERENCES FROM DIVERSITY
167
HUMANS AS APES
225
WHAT GENETIC CHANGES HAVE MADE US HUMAN?
257
AGRICULTURAL EXPANSIONS
363
INTO NEWFOUND LANDS
409
WHAT HAPPENS WHEN POPULATIONS MEET
443
UNDERSTANDING THE PAST PRESENT AND FUTURE OF PHENOTYPIC VARIATION
477
EVOLUTIONARY INSIGHTS INTO SIMPLE GENETIC DISEASES
517
EVOLUTION AND COMPLEX DISEASES
541
IDENTITY AND IDENTIFICATION
571
Appendix
601

ORIGINS OF MODERN HUMANS
283
THE DISTRIBUTION OF DIVERSITY
319
THE COLONIZATION OF THE OLD WORLD AND AUSTRALIA
341
Glossary
609
Index
641
Copyright

Other editions - View all

Common terms and phrases

About the author (2013)

Mark Jobling

earned a degree in Biochemistry and a DPhil at the University of Oxford, UK, and in 1992 came to the University of Leicester, UK, where he is now a Wellcome Trust Senior Fellow in Basic Biomedical Sciences and Reader in Genetics. Mark's interests are in Y chromosome diversity as a tool for addressing questions in human evolution, genealogy and forensics, and also male infertility and haploid mutation processes.

Matthew Hurles

earned his degree in biochemistry at Oxford University, UK, and PhD in Leicester, UK. He was until recently a Research Fellow at the McDonald Institute for Archaeological Research at Cambridge University, UK, analyzing genetic variation with the aim of improving our understanding of the human past. He is now at the Wellcome Trust Sanger Institute near Cambridge, UK, investigating the unusual evolutionary dynamics of recently duplicated genomic regions.

Chris Tyler-Smith

earned his degree in biochemistry at Oxford University, UK, and PhD in Edinburgh, UK. For the last few years he has been a University Research Lecturer in the Biochemistry Department at Oxford, UK, working on the structure and function of human centromeres, and the application of Y-chromosomal DNA variation to the understanding of the human past. He is now at the Wellcome Trust Sanger Institute near Cambridge, UK, studying the genetic changes that have taken place during recent human evolution.