Stem Cells: A Very Short IntroductionThe topic of stem cells has been very high profile in the media in recent years. There is much public interest in stem cells but also much confusion and misinformation, with some companies already offering 'stem cell products' and bogus 'stem cell therapies'. In this Very Short Introduction, Jonathan Slack introduces stem cells; what they are, what scientists do with them, what stem cell therapies are available today, and how they might be used in future. Despite important advances, clinical applications of stem cells are still in their infancy. Most real stem cell therapy today is some form of bone marrow transplantation. Slack introduces stem cells by explaining the difference between embryonic stem cells, which exist only in laboratory cultures, and tissue-specific stem cells, which exist in our bodies. Embryonic stem cells can become any cell type in the body, so diseases that may in future be treated by functional cells derived from these sorts of stem cell include diabetes, Parkinson's disease, heart disease, and spinal trauma. He then goes on to discuss the properties of tissue-specific stem cells and the important technique of bone marrow transplantation. Slack concludes by analysing how medical innovation has occurred in this area in the past, and draws out some of the lessons for the development of new therapies in the future. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. |
Contents
What are stem cells? | 1 |
Embryonic stem cells | 19 |
Personalized pluripotent stem cells | 34 |
Potential therapies using pluripotent stem cells | 50 |
Tissuespecifi c stem cells | 70 |
Current therapy with tissuespecifi c stem cells | 87 |
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adult allogeneic animal experiments aspirational stem cell become beta cells blastocyst bone marrow transplantation brain BrdU cancer cardiomyocytes cell lines cell populations cell turnover cell types clinical trials cures damage diabetes differentiated cell dividing cells donor dopaminergic neurons drugs embryo embryonic development embryonic stem cells epidermis epithelial ethical feeder cells fibroblasts function genes genetic germ layers graft rejection growth factors haematopoietic stem cells hormone host HSCs HSCT human embryos human ES cells immune system immunosuppression implanted induced pluripotent stem injected inner cell mass insulin intestine involves iPS cells islets liver lymphocytes methods mice molecules mouse ES cells neurons neurospheres normal oocyte organ pancreas Parkinson's disease patients pluripotent stem cells problems procedure produce protein rationale renewal tissues scientists skin specific stage stem cell research stem cell therapy teratomas therapeutic cloning therapies using pluripotent tissue culture tissue types tissue-specific stem cells transit amplifying cells treatment tumour vitro