Autonomic NeuroimmunologyWhile it may appear that the nervous and immune systems exist as two separate entities, groundbreaking observations have positively identified anatomic connections between elements of the nervous system and cells of adaptive immunity. Building on this research, Autonomic Neuroimmunology presents a scientific discussion of the current understanding of these vital neuroimmunological interactions and their implications for normal psychology and disease states. Contributors document the cell biological mechanisms for the neuropeptide activation of mast cells, and analyze how one or more adrenergenic and peptidergic messengers modulate immunity. They also explain the pathways by which cholinergic factors may suppress immunological inflammation. The potential implications of organ system-selective neuroimmunology for host defense and diseases are thoroughly discussed for the skin, the intestines, the bladder, and the lungs. With modern neuroimmunology now firmly established as a scientific discipline, this volume supports this promising science as a pathway to novel diagnostic and therapeutic techniques for diseases of the neural, immune, and endocrine systems. |
Contents
1 Sympathetic Innervation of the Immune System and its Role in Modulation of Immune Responses ImmuneRelated Diseases Models and Integrative... | 1 |
2 Interactions between the Adrenergic and Immune Systems | 15 |
3 Enteric Neural Reflexes and Secretion | 34 |
4 The Cholinergic AntiInflammatory Pathway | 59 |
5 Developmental Regulation and Functional Integration by the Vasoactive Intestinal Peptide VIP Neuroimmune Mediator | 72 |
6 An Emerging Role for Calcitonin GeneRelated Peptide in Regulating Immune and Inflammatory Functions | 93 |
7 Substance P and the Immune System | 109 |
8 NerveMast Cell InteractionsPartnership in Health and Disease | 137 |
Implications for Inflammation and Pain | 196 |
11 Functional Consequences of Neuroimmune Interactions in the Intestinal Mucosa | 215 |
12 Infectious Pathogens and the Neuroenteric System | 252 |
13 Neuroimmune Interactions in the Lung | 280 |
14 Neuroimmune Control of the Pulmonary Immune Response | 296 |
15 Regulatory Aspects of Neuroimmunology in the Skin | 319 |
16 Neuroimmune Connections and Regulation of Function in the Urinary Bladder | 345 |
| 371 | |
9 Submandibular Gland Factors and Neuroendocrine Regulation of Inflammation and Immunity | 169 |
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action activation afferent airway allergic animals antagonist antigen associated autonomic binding bladder blood brain calcitonin causes central CGRP challenge changes cholinergic colonic cystitis cytokines demonstrated differentiation direct disease effects enhanced enteric epithelial et al evidence expression Figure function gene glands guinea pig histamine hormone human immune immune responses immune system Immunol Immunology important increased induced infection inflammation inflammatory inhibited inhibitory innervation interactions intestinal involved jejunum Journal levels lymphocytes macrophages mast cells mechanisms mediators mice modulate mouse mRNA mucosal murine nerve nervous system neural neurons neuropeptides NK1 receptor normal observed organs pathways patients peptide peripheral Pharmacol Physiol potential production protein reactions recently receptor reflex regulation release response role schistosomiasis secretion sensitized sensory showed shown signalling skin specific stimulation stress studies submucosal substance suggesting sympathetic tachykinins tissue toxin transport vasoactive intestinal vitro