Plasticity in the Adult Brain: From Genes to NeurotherapyM.A. Hofman, G.J. Boer, Eus JW Van Someren, J. Verhaagen, D.F. Swaab, A.J.G.D. Holtmaat In the past decade neuronal plasticity has become a major theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in worms and insects to behavioural recovery from strokes in elderly humans. For this reason the focus of interest in the present volume of Progress in Brain Research is on the topic of neuroplasticity in mature organisms, including humans. Contributions range from neurogenesis and synaptic plasticity in the adult primate brain, to neural mechanisms of learning and memory, and the influence of environmental factors and aging on the functional potential of the central nervous system. Several contributions focus on recent developments in neural regeneration and brain repair, providing challenging evidence that the use of stem cell neurotherapy may be beneficial to humans suffering from various neurological and psychiatric diseases. This volume integrates new information on the cellular and molecular mechanisms of neuroplasticity and highlights challenging future questions in this exciting and topical area of neuroscience. |
Contents
| 15 | |
Learning and memory | 89 |
Circadian and seasonal plasticity | 189 |
Neural plasticity in aging and neuropathology | 281 |
Cell implantation and gene therapy | 395 |
Stem cells Their role in brain repair | 433 |
| 471 | |
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activity addition adult aging alterations Alzheimer’s disease animals appears areas associated axons BDNF behavioral Biol blind Brain Res cells changes circadian clock cognitive Comp compared complex cortex cortical decrease dendritic dentate gyrus dependent differential early effects enhanced enrichment environment environmental estrogen et al evidence experience expression formation function gene glucose hippocampal human important increased indicate induced injection input involved lateral layer learning lesions levels light long-term loss mechanisms memory mice molecular monkeys Nature nerve Neurobiol neurogenesis neurons Neurosci neurotrophins normal nucleus observed occur pathway patients patterns period phase plasticity potentiation present processes projections protein rats recent receptor regions regulation reported Research response rhythms role Science seasonal semaphorins sensory signaling sleep specific spines stimulation structure studies subjects suggest suprachiasmatic Swaab synaptic tion treatment
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