Chernick-Mellins Basic Mechanisms of Pediatric Respiratory DiseaseThis second edition of the landmark 1991 text will review the cellular and integrative aspects of the biology of the developing respiratory system. It will be an important resource to researchers in the subspec ialty of pediatric pulmonology and to practitioners who wish science t o inform their clinical decisions. The text will be an authoritative, comprehensive, and current summary of the scientific foundation of ped iatric pulmonology. |
From inside the book
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Contents
SECTION I GENETIC AND DEVELOPMENTAL BIOLOGY OF THE RESPIRATORY SYSTEM | 1 |
CHAPTER 2 Genetic and Molecular Basis of Airway and Lung Development | 9 |
Surfactant Protein B Deficiency | 24 |
CHAPTER 4 Developmental Biology of Surfactant | 37 |
SECTION II STRUCTUREFUNCTION RELATIONS OF THE RESPIRATORY SYSTEM DURING DEVELOPMENT | 49 |
CHAPTER 6 Tissue Interactions in Lung Organogenesis | 68 |
CHAPTER 7 Prenatal and Postnatal Development of the Pulmonary Circulation | 77 |
CHAPTER 8 Responses of the Developing Lung to Injury | 102 |
CHAPTER 22 Disorders of Ion Transport | 294 |
CHAPTER 23 Cellular and Molecular Mechanisms in Hypoxic Injury or Adaptation | 312 |
CHAPTER 24 Effects of Hypoxia on the Developing Pulmonary Circulation | 328 |
CHAPTER 25 Regulation of Cerebral Vascular Function by Oxygen | 345 |
CHAPTER 26 Cardiopulmonary Physiology at Altitude | 356 |
CHAPTER 27 Laryngeal Function and Respiratory System Neural Reflexes | 377 |
CHAPTER 28 Fetal Respiratory Control and Changes at Birth | 386 |
CHAPTER 29 Postnatal Development of Respiratory Control | 398 |
CHAPTER 9 Development of the Thoracic Cage | 124 |
CHAPTER 10 Structural and Functional Development of Respiratory Muscle | 139 |
SECTION III DEVELOPMENTAL PHYSIOLOGY OF THE RESPIRATORY SYSTEM | 154 |
CHAPTER 12 Comparative Aspects of Neonatal Respiratory Mechanics | 171 |
CHAPTER 13 Physiology of Cough | 179 |
CHAPTER 14 Oxygen Transport | 184 |
CHAPTER 15 Pulmonary Gas Exchange | 200 |
CHAPTER 16 Tissue and Cellular Carbon Dioxide Transport and AcidBase Balance | 216 |
CHAPTER 17 HeartLung Interactions | 234 |
Implications for Ventilatory Failure | 250 |
CHAPTER 19 Airway Smooth Muscle | 261 |
CHAPTER 20 Pulmonary Edema and Injury to the Developing Lung | 272 |
CHAPTER 21 Ion Flux and Homeostasis in the Lung | 285 |
CHAPTER 30 Sleep and Respiratory Control | 412 |
CHAPTER 31 Interacting Mechanisms of Physical Activity and Growth in Children | 431 |
SECTION IV INFLAMMATION AND PULMONARY DEFENSE MECHANISMS | 445 |
CHAPTER 33 Ciliogenesis of Airway Epithelium | 452 |
CHAPTER 34 Immunology and Cellular Defense Mechanisms in the Lung | 465 |
CHAPTER 35 Airway Secretions | 472 |
Origins Functions and Clearance | 489 |
CHAPTER 37 The Role of Oxidant Injury in the Pathogenesis of Bronchopulmonary Dysplasia | 505 |
CHAPTER 38 VirusInduced Inflammation in Airways | 518 |
Molecular Mediators and Pathophysiologic Relevance | 528 |
| 537 | |
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Common terms and phrases
abnormal acid activity acute adult altitude alveolar alveoli angiogenesis Appl Physiol breathing bronchopulmonary dysplasia capillary cardiac Cell Mol Biol cellular CFTR changes channels chronic ciliogenesis Clara cells clinical CO₂ cystic fibrosis cytokines decrease diaphragm differentiation effects embryonic endoderm endothelial cells epithelial cells epithelium expression extracellular fetal lung fibers fibroblast Figure fluid function gene genetic growth factor human hypercapnia hypoxemia hypoxia hypoxic IGF-I increase induced infants infection inflammatory inhibition interactions kinase lung development lung disease lung injury macrophages mature mechanisms mediated membrane mesenchyme metabolic mice molecules monary morphogenesis mouse mRNA mutations neonatal neurons newborn normal O₂ oxygen pathways patients Pediatr Pediatr Res postnatal pressure preterm pulmonary hypertension pulmonary vascular receptor regulation Respir Cell Mol Respir Crit respiratory response Rev Respir role secretion sleep smooth muscle smooth muscle cells SP-A SP-B stimulation studies surfactant protein syndrome tion tissue tracheal transport VEGF venous ventilation ventilatory vitro vivo