Bioactive Natural Products: Detection, Isolation, and Structural Determination, Second EditionSteven M. Colegate, Russell J. Molyneux Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development. |
Contents
| 1 | |
| 11 | |
Strategies for Structural Determination | 77 |
Chapter 4 Quantitative NMR of Bioactive Natural Products | 113 |
Chapter 5 Development and Application of LCNMR Techniques to the Identification of Bioactive Natural Products | 143 |
Chapter 6 Determination of the Absolute Configuration of Bioactive Natural Products Using Exciton Chirality Circular Dichroism | 191 |
Chapter 7 Separation of Enantiomeric Mixtures of Alkaloids and Their Biological Evaluation | 209 |
Chapter 8 Dereplication and Discovery of Natural Products by UV Spectroscopy | 221 |
Chapter 13 Sourcing Natural Products from Endophytic Microbes | 371 |
Chapter 14 Isolation of Bioactive Natural Products from Myxobacteria | 391 |
Chapter 15 Naturally Occurring Glycosidase Inhibitors | 407 |
Chapter 16 BioassayDirected Isolation and Identification of Antiaflatoxigenic Constituents of Walnuts | 421 |
Chapter 17 Bioactive Peptides in Hen Eggs | 439 |
Strategy for Screening Bioactive Compounds in Traditional Chinese Medicines | 459 |
Chapter 19 Antimalarial Compounds from Traditionally Used Medicinal Plants | 491 |
Isolation and Identification | 531 |
Chapter 9 Liquid ChromatographyMass Spectrometry in Natural Product Research | 245 |
Chapter 10 Application of HighSpeed Countercurrent Chromatography to the Isolation of Bioactive Natural Products | 267 |
Chapter 11 Biosensing Approach in Natural Product Research | 299 |
Chapter 12 Anticancer Drug Discovery and Development from Natural Products | 323 |
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Common terms and phrases
acid activity addition agents alkaloids analysis analytical antimalarial application approach assay binding bioactive bioassay biological cancer cell Chem chemical Chromatogr chromatography clinical column complex components compounds concentration containing correlation coupling crude derivatives described detection determination discovery drug effects elution endophytic evaluation example experiments extract Figure Food fraction HPLC HSCCC human identification important indicated inhibition inhibitors interaction isolated known LC-NMR limited major marine mass measured medicinal metabolites method mixture molecular molecules natural products novel observed obtained OH OH organic peak peptides phase plant potential preparative present Prod protein pulse range recent reported Reson sample screening selective sensitivity separation showed shown signals similar solvent species spectra spectrum standard structure synthesis techniques tion toxicity treatment values vitro