Genes & Signals

Front Cover
CSHL Press, 2002 - Science - 192 pages
Genes & Signals analyzes gene regulation from a new perspective. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms. A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.
 

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Contents

Lessons from Bacteria
11
THE BACTERIOPHAGE A
26
Making an Efficient Switch
34
Antitermination N and Q
38
Phage T4 Late Genes
47
FOOTNOTES
53
A Singlecelled Eukaryote
59
HOW GalA WORKS
67
BIBLIOGRAPHY
110
RECRUITMENT
116
DETECTING AND TRANSMITTING PHYSIOLOGICAL SIGNALS
123
ACTION AT A DISTANCE
129
COMPARTMENTALIZATION
135
Enzyme Specificity and Regulation
143
INTERIM SUMMARY AND EXTENSIONS
156
FOOTNOTES
167

Activator Bypass Experiments
81
SIGNAL INTEGRATION AND COMBINATORIAL CONTROL
92
Variegation Visualized
99
Topogenic Sequences
183
Copyright

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Page 175 - The difficulty lies, not in the new ideas, but in escaping from the old ones, which ramify, for those brought up as most of us have been, into every corner of our minds.
Page 144 - Bell, AC, and Felsenfeld, G. (1999). Stopped at the border: boundaries and insulators. Curr Opin Genet Dev 9, 191-198.
Page 143 - Taniguchi, T., Ogasawara, K., Takaoka, A. and Tanaka, N. (2001). IRF family of transcription factors as regulators of host defense. Annu Rev Immunol 19. 623-655.
Page 143 - Glass, CK, and Rosenfeld, MG (2000). The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev., 14, 121-141.
Page 59 - Salas M. 1998. Transcription activation and repression by interaction of a regulator with the a subunit of RNA polymerase: The model of phage <(>29 protein p4.
Page 112 - Orphanides, G., Lagrange, T., and Reinberg, D. (1996) The general transcription factors of RNA polymerase II. Genes Dev. 10, 2657-2683.
Page 58 - Gaal. 2000. UPs and downs in bacterial transcription initiation: the role of the a subunit of RNA polymerase in promoter recognition. Mol. Microbiol. 37:687-695. 31. Griffith, KL, IM Shah, TE Myers, MC O'Neill, and RE Wolf, Jr. 2002. Evidence for "pre-recruitment...
Page 112 - Epigenetic Mechanisms of Gene Regulation. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY 13.
Page 59 - Rombel, I., North, A., Hwang, I., Wyman, C. and Kustu, S. (1998) Cold Spring Harbor Symp Quant Biol. 63, 157-166.

About the author (2002)

Alexander Gann (the Lita Annenberg Hazen Dean-Elect) is a member of the faculty of the Watson School of Biological Sciences.

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