The Evolution of HIV

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Keith A. Crandall
JHU Press, Apr 26, 1999 - Medical - 504 pages
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The HIV epidemic has spawned a scientific effort unprecedented in the history of infectious disease research. This effort has merged aspects of clinical research, basic molecular biology, immunology, cell biology, epidemiology, and mathematical biology in ways that have not been seen before. In The Evolution of HIV Keith A. Crandall brings together researchers from these disciplines to present perspectives on both the molecular biology and molecular evolution of HIV.

The book is organized into three sections: "Introduction to HIV" explores the fundamentals of the virus's molecular biology and its global diversity. "Molecular Methods for Studying HIV Diversity" looks at such topics as HIV phylogenetics, modeling the molecular evolution of HIV sequences, the use of phylogenetic inference to test an HIV transmission hypothesis, and coalescent approaches to HIV population genetics. The third section,"Case Studies of HIV Evolution" examines the levels of diversity within and among host individuals, the phylogenetics of known transmission histories, and HIV evolution and disease progression via longitudinal studies.

The book will be of interest to researchers and clinicians working on HIV, as well as scientists studying molecular evolution, population genetics, and evolutionary biology. Contributors are John M. Coffin, Keith A. Crandall, Joseph Felsenstein, Walter M. Fitch, Brian Foley, Esther Guzman, Paul H. Harvey, David M. Hillis, Edward C. Holmes, Marcia L. Kalish, Bette T. M. Korber, Julia Krushkal, Carla L. Kuiken, Gerald H. Learn, Thomas Leitner, Wen-Hsiung Li, Francine E. McCutchan, Spencer V. Muse, Oliver G. Pylons, Allen G. Rodrigo, Raj Shankarappa, Richard W. Steketee, Alan R. Templeton, Donald M. Thea, Raphael P. Viscidi, Steven M. Wolinsky.

 

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This is great information as an HIV learning source. A very useful online reading tool for public health epidemiology scholar practitioners. ~ Pattye FNP

Contents

Global Diversity in HIV
41
Brian Foley
42
Jackson Foundation for the Advancement of Military
76
Molecular Methods for Studying HIV Diversity
103
Modeling the Molecular Evolution of
122
Los Alamos NM 87545
151
Statistical Approaches to Detecting
153
The Molecular Population Dynamics of HIV1
177
Coalescent Approaches to HIV Population
233
Levels of Diversity within and among Host
275
The Phylogenetics of Known Transmission
315
HIV Evolution and Disease Progression
346
Perinatal HIV Infection
390
Determinants of HIV1 Protein Evolution
432
Health Sciences Center K443
443
Theoretical Biology and Biophysics
462

Department of Zoology
204
Department of Zoology
206
Use of Phylogenetic Inference to Test an
208
Evolution of HIV1 Resistance to Antiviral
469
Index
491
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Page 484 - Treatment with lamivudine, zidovudine, or both in HIV-positive patients with 200 to 500 CD4+ cells per cubic millimeter. N. Engl. J. Med.
Page 484 - Finzi D, Hermankova M, Pierson T, Carruth LM, Buck C, Chaisson RE, Quinn TC, Chadwick K, Margolick J, Brookmeyer R, Gallant J, Markowitz M, Ho DD, Richman DD, Siliciano RF (1997) Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.

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About the author (1999)

Keith A. Crandall is assistant professor of zoology at Brigham Young University.

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