Pediatric Tumors: Immunological and Molecular MarkersThis monograph explains the considerable impact that monoclonal antibodies and molecular probes have had on the diagnosis of tumor types and sub-types. It explains how radiolabelled monoclonal antibodies have also been used as imaging agents to try to improve the oncologist's ability to define residual tumor deposits after combination chemo/radiotherapy. Finally, the childhood malignancies that still have a poor prognosis are presented, and new novel ways of therapy are explained. |
Contents
Introduction | 2 |
Collaborative Investigations and Classifications | 4 |
Light Microscopic Methods of Diagnosis | 9 |
Ultrastructural Examination | 14 |
Immunohistology | 17 |
Histochemistry and Cytochemistry | 21 |
In Vitro Culture | 23 |
Cytogenetics | 24 |
Chapter 1 | 31 |
Chapter 3 | 47 |
Chapter 4 | 69 |
Chapter 5 | 85 |
Chapter 7 | 105 |
Chapter 8 | 125 |
Chapter 9 | 153 |
Chapter 10 | 171 |
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Common terms and phrases
abnormalities acute lymphoblastic acute lymphoblastic leukemia analysis aniridia antigen expression astrocytoma autologous bone marrow binding biopsy bone marrow transplantation Cancer Res carcinoma cell lymphoma cell receptor chain chromosomal translocations chromosome 11 Clin clinical clonal clone complement conjugate Cytogenet cytoplasmic deletion demonstrated detected diagnosis Differentiation Antigens disease dose enolase enzyme Ewing's sarcoma fetal Figure fragments gene rearrangement Genet genome GFAP glial glioma hepatoblastomas histological identified Ig genes immunoglobulin immunohistological Immunol intermediate filament Kemshead leukemic levels locus lymphocytes malignant markers medulloblastoma metastatic mIBG molecular monoclonal antibodies murine N-myc amplification Natl neoplastic neural neuroblastoma neuroblastoma cell line neuroectodermal neurofilament neuronal normal oncogene Pathol patients pediatric phenotype probes Proc prognosis protein purging radiolabeled reactivity reagents recombination region relapse remission retinoblastoma rhabdomyosarcoma Seeger sequences serum small round cell specific staining studies target techniques therapy tissue translocation treatment tumor cells tumors of childhood uptake vimentin vitro Wilms Zeltzer