DNA Structure and FunctionDNA Structure and Function, a timely and comprehensive resource, is intended for any student or scientist interested in DNA structure and its biological implications. The book provides a simple yet comprehensive introduction to nearly all aspects of DNA structure. It also explains current ideas on the biological significance of classic and alternative DNA conformations. Suitable for graduate courses on DNA structure and nucleic acids, the text is also excellent supplemental reading for courses in general biochemistry, molecular biology, and genetics.
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Contents
CHAPTER | 1 |
CHAPTER 2 | 58 |
CHAPTER 3 | 95 |
CHAPTER 4 | 134 |
CHAPTER 5 | 179 |
CHAPTER 6 | 217 |
CHAPTER 7 | 259 |
Genetic Disease | 283 |
CHAPTER 9 | 326 |
Bibliography | 353 |
| 387 | |
| 393 | |
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Common terms and phrases
agarose gel amino acids anti antibody assay B-DNA B-form DNA binding proteins chemical chromosome coiling coli cross-links cruciform cruciform formation cytosine dimer dinucleotide direct repeat DNA bending DNA double helix DNA gyrase DNA molecule DNA replication DNA sequences DNA structure DNA supercoiling double helix double-stranded duplex electrophoresis enzyme eukaryotic eukaryotic cells gene expression guanine helical turns Hoogsteen base pairs hydrogen bonding interaction intramolecular triplex DNA intramolecular triplex structure inverted repeat isomer junction left-handed level of supercoiling linear linking number loop major groove migration mirror repeat mispaired negative supercoils nick nucleosomes nucleotide occur organization phosphate backbone photobinding plasmid positive supercoils protein psoralen purine pyrimidine region of DNA relaxed DNA repressor ribose RNA polymerase rotation shown in Figure Sinden single-stranded specific ẞ sheet stability supercoiled DNA superhelical density T-rich temperature third strand thymine tion topoisomerase topoisomers topological domain tracts unwinding vivo Watson-Crick Z-DNA
Popular passages
Page 383 - Workman, JL and Roeder, RG (1987) Binding of transcription factor TFIID to the major late promoter during in vitro nucleosome assembly potentiates subsequent initiation by RNA polymerase II. Cell 51, 613-622.
Page 371 - Negatively supercoiled plasmids contain left-handed ZDNA segments as detected by specific antibody binding. Cell 31, 309-318.
Page 358 - Duckett, DR, Murchie, AIH, Diekmann, S., von Kitzing, E., Kemper B., and Lilley, DMJ (1988) The structure of the Holliday junction, and its resolution. Cell 55, 79-89.
Page 373 - Drlica K (1982) Escherichia coli DNA topoisomerase I mutants: increased supercoiling is corrected by mutations near gyrase genes. Cell 31 :35-42 Richardson SM, Higgins L, Lilley D (1984) The genetic control of DNA supercoiling in Salmonella typhimurium.
Page 358 - Interaction of origin binding protein with an origin of replication of herpes simplex virus 1.