HLA and DiseaseRobert Lechler This text describes the genetics and products of the HLA region and their relationship to diseases including diabetes, rheumatoid arthritis and SLE. The statistical principles relevant to the design and interpretation of HLA and disease studies are presented in simple and accessible language. |
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amino acids analysis ankylosing spondylitis antigen presentation aẞ autoimmune diseases cell line cell surface chi-square class I antigens class II expression class II genes class II molecules class II region clones complement controls deletion detected dimers disease associations disease susceptibility distribution domain DQB1 DRB1 factors frequency function genes encoding genetic haplotypes HLA and disease HLA antigens HLA class HLA molecules HLA region HLA-A HLA-DR IDDM immune response Immunogenetics Immunol induction interaction invariant chain linkage disequilibrium loci locus lymphocytes major histocompatibility complex MHC class MHC class II MHC molecules molecular mouse multiple sclerosis murine Natl Acad Nature null alleles observed patients peptide peptide antigens peptide binding polymorphism population possible Proc protein residues RFLP rheumatoid arthritis role sequence serological significance specific ẞ chains statistical structure subtypes susceptibility genes systemic lupus erythematosus T-cell receptor T-cell recognition Table thymus transfection typing