Advances in Immunology

Acad activity affinity amino acid amino acid sequence Amit antibody binding antibody-antigen antigen antigen receptor antipeptide antisera Berzofsky Biol Brenner Brenner et al Caº cDNA CDRs cell clones cell lines cell receptor cell surface Chothia Colman complex conformational changes critical residues crystallographic cytochrome determined domains electrostatic elements encoded epitopes exon expression factors fetal fragment function gene segments Getzoff Geysen hapten heavy chain hexapeptide histocompatibility homologous human T cell human TCR hybridoma hydrophilicity hydrophobic identified Igh enhancer immune response immunoglobulin Immunol immunological interaction interface light chain loops lymphocytes lysozyme MHC molecules mobility molecules monoclonal antibodies mouse murine myoglobin Natl Nature London observed octamer peptide polypeptide predicted probe Proc promoter protein antigen reactivity recognition recognized region sequential epitopes shown side chains specificity structure studies subunit suggest T-cell Tainer TCR yö TCR yò cells thymocytes thymus transcription variable vitro