Cytokines and Cytokine Receptors: Physiology and Pathological DisordersThe field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic |
Contents
Interleukin2 Interleukin15 and Their Receptors | xiii |
Leukemia Inhibitory Factor Part Of A Large Ingathering Family | xix |
Cytokines in Hematopoiesis | 17 |
Interleukin4 and Interleukin13 Commonalities and Differences | 35 |
Biological and Molecular Characteristics Of Interleukin5 and Its Receptor | 63 |
Interleukin6 and Its Receptor | 74 |
TNF and TNF Receptor Superfamily | 96 |
Genetic Deficiency in Tumor Necrosis Factor Receptors | 127 |
Type I Interferons | 294 |
TGFβ From Gene Targeting to Gene Therapy | 312 |
Cytokine Receptors Structures and Signal Transduction | 333 |
Signal Transduction Through Cytokine Receptors | 343 |
Transcriptional Regulation of Cytokine Genes | 351 |
Human Th1Th2 Cells In Health and Disease | 366 |
Cytokines and Cancer | 383 |
Subterfuges and Sabotage Virus Manipulation of Cytokine Networks | 395 |
Interleukin7 a Nonredundant Potent Cytokine Whose OverExpression Massively Perturbs Blymphopoiesis | 145 |
Interleukin7 il7 Knock Out Mice Implications for Lymphopoiesis and Organspecific Immunity | 161 |
Lymphocyte Responses to Chemokines | 176 |
Interleukin9 and Its Receptor From Structure to Function | 194 |
Interleukin10 as a Key Regulator of Inflammation And Stress Responses | 207 |
Proinflammatory and Immunoregulatory Functions of Interleukin12 | 226 |
Signaling and Functional Properties of Interleukin16 | 244 |
Interleukin17 | 254 |
Spanning Innate and Adaptive Immunity A Role For Interleukin18 | 262 |
The Role of Interferony in Experimental Autoimmune Disease | 278 |
Cytokines and Chemokines in Hiv Infection Implications for Therapy | 419 |
Cytokines in Parasitic Diseases The Example of Cutaneous Leishmaniasis | 431 |
Cytokines in Autoimmune Disorders | 445 |
Cytokines in Organ Transplantation | 451 |
Cytokines and Human Reproduction | 461 |
Inherited Cytokine and Cytokine Receptors Defects in Man | 475 |
Cytokines in the Neuroendocrine System | 484 |
The Chronobiology of Human Cytokine Production | 506 |
Methods for Clinical Investigation of Cytokine and Cytokine Receptors | 515 |
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Common terms and phrases
Acad activation antibody antigen apoptosis arthritis autoimmune beta binding Biol biological blood bone marrow cancer CD4+ T cells CD8+ cDNA cell lines cellular chain Chem chemokine receptor Clin clinical clones cytokine receptors cytoplasmic cytotoxic defects deficient dendritic cells differentiation disease domain effects encoding enhances eosinophils function gene expression GM-CSF growth factor hematopoietic human IFN-y immune response Immunol induced infection inflammatory inhibits interaction interferon interleukin intracellular involved leukemia inhibitory factor levels ligand lymphocytes lymphoid macrophages mast cells mediated molecular molecules monocytes mouse mRNA murine mutation Natl NK cells normal pathway patients peptide phenotype phosphorylation pituitary Proc proliferation promoter protein receptor family recombinant regulation role secretion sequence signal transduction soluble specific STAT STAT3 stimulation subunit T-cell TGF-B TGF-ẞ Th2 cells tion tissue TNFa transcription factors transforming growth transgenic mice Transplantation tumor necrosis factor viral virus vitro vivo