Sructure of Antigens, Volume 1Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms). Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity. VOLUME 1 |
Contents
Molecular Dissection of Protein Antigens | 1 |
Structure of Protein Epitopes Deduced from | 29 |
Antigen Mimicry with Synthetic Peptides | 43 |
Prediction of T CellRecognized Epitopes | 81 |
AntigenAntibody Reactions | 99 |
Measurement of Antibody Affinity | 127 |
Maturation of the Immune Response | 149 |
Precipitation and Agglutination | 179 |
Common terms and phrases
Absolom Acad activity adjuvant adsorbed adsorption affinity Ag-Ab agglutination alleles amino acid analysis anti anti-Id anti-idiotypic antigen antigen-antibody antigenic determinants assay binding Biochem Biol bonds bound Butler cell-presented cells Chem class I molecules complex concentration conformation covalent cross-reactivity detection dissociation ELISA enzyme epitopes erabutoxin erythrocytes expressed functional gene glycoprotein hapten heavy chain helices helix hemagglutination histocompatibility HLA class human hydrophobic hydrophobic strip idiotypic IgG1 IgG3 immobilized immune response immunoassay immunochemical Immunochemistry immunogenic immunoglobulin Immunol immunological induced infection inhibition interaction interfacial isotype kinetics ligands loop lymphocytes lysozyme MAbs membrane Ménez Meth method mimic mimicry molecular molecules monoclonal antibodies mutations Naja nigricollis Natl Nature London paratope peptide polyclonal polymers polypeptide precipitate predicted primary Proc protein protein antigens reactants reaction reagents receptor recognition recognized Regenmortel region serum snake solid-phase specific structure studies subclasses surface synthetic peptides T-cell toxin vaccine venom viral