Hypolipidemic Agents

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Springer Science & Business Media, Dec 6, 2012 - Medical - 490 pages
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The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term would be hyperlipoproteinemia. This volume represents an effort to elucidate the origins and metabolic behavior of lipoproteins and their components, to describe aspects of the morphology, biochemistry and experimental induction of ASHD, and to describe modalities of treatment. The contributions to this book include descriptions of cholesterol synthesis and metabolism, as well as the metabolism of bile acids, the principal products of cholesterol metabolism. There are also chapters on the mechanisms of hyperlipidemia and on lipoprotein metabolism. The induction of experimental atherosclerosis and the aortic structural changes caused by this disease are discussed.
 

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Contents

CHAPTER
1
List of Contributors
4
Preparations and Activity Assays
12
References
26
Plasma Cholesterol
61
Proposed Model for Cholesterol Metabolism in Man
80
References
90
CHAPTER 3
109
Primates
221
CHAPTER 7
228
Regulation of Lipoprotein Secretion
248
Concluding Remarks
265
CHAPTER 8
291
Concluding Remarks
330
CHAPTER 9
349
Catecholamines Adrenergic Blocking Agents
358

Regulation of Cholesterol Catabolism via Bile Acids
122
Effects of Hormones on Bile Acids
129
CHAPTER 4
151
Classification of Hyperlipidemias
168
References
182
CHAPTER 5
190
Lipoprotein Metabolism
200
The Hyperlipoproteinemias
206
CHAPTER 6
215
Substituted Phenyl and Phenyloxyacetic Acids
371
Extrahepatic Enzymes Influenced by Clofibrate
380
Compounds Containing Sulfur
385
Rifampin
392
CHAPTER 10
409
Author Index 417
416
Subject Index
483
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