W.L. Bencze, D. Kritchevsky, M.E. Dempsey, S. Eisenberg, J.M. Felts, I.D. Frantz, R. Hess, R.I. Levy, T.A. Miettinen, L.L. Rudel, H.S. Sodhi, W. Stšubli, T. Zempl;&AAe;nyi
Springer Science & Business Media, Dec 6, 2012 - Medical - 490 pages
The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term would be hyperlipoproteinemia. This volume represents an effort to elucidate the origins and metabolic behavior of lipoproteins and their components, to describe aspects of the morphology, biochemistry and experimental induction of ASHD, and to describe modalities of treatment. The contributions to this book include descriptions of cholesterol synthesis and metabolism, as well as the metabolism of bile acids, the principal products of cholesterol metabolism. There are also chapters on the mechanisms of hyperlipidemia and on lipoprotein metabolism. The induction of experimental atherosclerosis and the aortic structural changes caused by this disease are discussed.
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Regulation of Lipoprotein Secretion
Catecholamines Adrenergic Blocking Agents
Regulation of Cholesterol Catabolism via Bile Acids
Effects of Hormones on Bile Acids
Classification of Hyperlipidemias
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absorption acetate Acta Amst adipose tissue Amer aorta aortic Atheroscler atherosclerosis bile acids bile salt biliary Biochem biophys biosynthesis catabolism Cell Biol Chem choles cholesterol esters cholesterol levels cholesterol metabolism cholesterol synthesis cholestyramine cholic acid chylomicrons Circulation clin clofibrate concentration coronary CPIB decreased dehydrogenase diet dietary cholesterol DIETSCHY disease drug effect endogenous endoplasmic reticulum enzyme esterified excretion experimental faecal bile acids fatty acids fraction FREDRICKSON free cholesterol GRUNDY hepatic hormones human hyperlipoproteinemia hypolipidemic agents increased inhibition intestinal Invest KRITCHEVSKY KUDCHODKAR lesions LEVY Lipid Res lipolysis lipolytic activity lipoprotein lipase liver low density lipoproteins lymph lysosomal membranes mevalonate microsomal MIETTINEN nicotinic acid normal observed oxidation particles patients perfused peroxisomes phospholipids Physiol plasma plasma cholesterol plasma lipoproteins pool Proc protein rabbit radioactive rat liver secretion secretory serum cholesterol SODHI specific activity steroid sterols studies tion triglycerides turnover Type vascular vitro vivo VLDL ZEMPLENYI