Translational Control of Gene ExpressionNahum Sonenberg, John W. B. Hershey, Michael Mathews There is fresh interest in protein synthesis and recognition of the key role of translational control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the 1996 publication, Translational Control, but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control. |
Contents
20 | 3 |
Pathway and Mechanism of Initiation of Protein Synthesis | 33 |
The Protein Biosynthesis Elongation Cycle | 89 |
Copyright | |
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Translational Control of Gene Expression Nahum Sonenberg,John W. B. Hershey,Michael B. Mathews Limited preview - 2001 |
Common terms and phrases
40S ribosomal 40S subunit Acad activity amino acid amino-terminal binding Biochem Biol carboxy-terminal cells cellular Chapter Chem cytoplasmic domain downstream Drosophila eEF1A EF1A eIF1 eIF1A eIF2 eIF2a eIF2B eIF3 eIF4A eIF4B eIF4E eIF4F eIF4G eIF5 eIF5B elegans elongation factor EMBO embryos encoding Escherichia coli eukaryotic initiation factor eukaryotic translation initiation expression function GCN2 GCN4 Genes Dev genetic Gingras heat shock helicase Hershey J.W.B. Hinnebusch A.G. homolog hydrolysis inhibition initiation codon initiation complex initiator tRNA interaction mammalian mechanism mediated Met-tRNA motif mRNA mutations nanos Natl nucleotide nucleotide exchange oocytes pathway Pestova phenotype phosphorylation poly(A polyadenylation polysomes Proc prokaryotic protein kinase protein synthesis region regulatory repression residues reticulocyte ribosomal subunit RNA-binding role Saccharomyces cerevisiae scanning sequence Sonenberg specific stimulates structure termination ternary complex tion transcription translation initiation factor translational control translational regulation tRNA uORF viral virus viruses vitro vivo yeast