Immunological Aspects of the Vascular EndotheliumCaroline O. S. Savage, Jeremy D. Pearson Originally published in 1995, this volume looks at the functioning of the vascular endothelium, and the diseases and tissue injury that arise as a result of inflammation and immunological responses. The vascular endothelium is a metabolically highly active layer of cells lining all blood vessel walls. Through its interactions with leucocytes and other mediators, it is central to the development of inflammatory foci and to lymphocyte trafficking around the body. Tissue injury may arise here as a result of abnormal inflammatory or immune responses. The potential for such injury to contribute to autoimmune disease is discussed in this book, particularly in relation to autoimmune vascular disease of the renal, rheumatological and neurological systems, as well as in organ transplantation. |
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Immunological Aspects of the Vascular Endothelium Caroline O. S. Savage,Jeremy D. Pearson No preview available - 2011 |
Common terms and phrases
activation adhesion molecule-1 adhesion molecules allograft American Journal ANCA antigen artery Arthritis associated autoantibodies autoimmune binding cell adhesion cellular circulating class II MHC Clinical and Experimental Clinical Investigation clones cultured cytokines cytoplasmic cytotoxic endo endothelial cells endothelium Experimental Immunology Experimental Medicine expression gene glomerular GlyCAM-1 human endothelial cells immune complexes immune response immunoglobulin increased induced infiltration inflammation inflammatory inhibit integrin interactions interferon interleukin involved Journal of Clinical Journal of Experimental Journal of Immunology Journal of Pathology Kawasaki disease kidney L-selectin lesions leukocyte adhesion ligand lymph nodes lymphocyte migration lymphocytes mediated membrane MHC class MHC molecules monoclonal antibody monocytes mononuclear nervous system neutrophils pathogenesis patients peptide peripheral PGI2 plasma platelet Pober protein receptor regulation Remuzzi renal rheumatoid role scleroderma sclerosis selectin Sjögren's syndrome stimulation studies synovial systemic vasculitis tissue Transplantation vascular endothelial cells venules vitro vivo von Willebrand factor Wegener's granulomatosis