Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes

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Franco Cataldo, Tatiana da Ros
Springer Science & Business Media, Sep 8, 2008 - Science - 408 pages

Fullerenes and nanotubes are two classes of carbon structures or allotropes, which were discovered about 17 years ago. Since that time, many chemical derivatives have been synthesized using fullerenes and nanotubes as building blocks.

Particularly promising was the theory that the chemical properties of fullerenes, and certain derivatives, made them likely candidates for anticancer drugs, inhibitors of viruses such as HIV, or even as anti-bacterials. Their cyctotoxicity can also be controlled by specific circumstances.

In addition, the funtionalization of nanotubes has not only produced relatively simple derivatives, but also complex hybrids with biological macromolecules, which show unique supramolecular architecture and which are promising in many medical applications.

The application of fullerenes and nanotubes in medicine is at the frontier of our knowledge, thus the work in this field represents the basis for future novel developments.

 

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Contents

Twenty Years of Promises Fullerene in Medicinal Chemistry
1
Biomedical Applications of Functionalised Carbon Nanotubes
23
Antioxidant Properties of WaterSoluble Fullerene Derivatives
51
Fullerenes as Photosensitizers in Photodynamic Therapy
79
Photodynamic Inactivation of Enveloped Viruses by Fullerene Study of Efficacy and Safety
107
Effects of Photoexcited Fullerene C60Composites in Normal and Transformed Cells
122
Biological Effects in Cell Cultures of Fullerene C60 Dependence on Aggregation State
139
Gadolinium Endohedral MetallofullereneBased MRI Contrast Agents
156
Visualization of Carbon Nanoparticles Within Cells and Implications for Toxicity
267
Pharmacological Applications of Biocompatible Carbon Nanotubes and Their Emerging Toxicology Issues
283
Solubility of Fullerenes in Fatty Acids Esters A New Way to Deliver In Vivo Fullerenes Theoretical Calculations and Experimental Results
317
New Approach to QSPR Modeling of Fullerene C60 Solubility in Organic Solvents An Application of SMILESBased Optimal Descriptors
336
Functionalized Nanomaterials to Sense ToxinsPollutant Gases Using Perturbed Microwave Resonant Cavities
351
Cellular Nanotubes Membrane Channels for Intercellular Communication
363
Index
373
Color Plates
379

Biomolecules Functionalized Carbon Nanotubes and Their Applications
181
Applications of CarbonBased Nanomaterials for Drug Delivery in Oncology
223

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