Skin BarrierPeter M. Elias, Kenneth R. Feingold A must-have reference for any researcher or scientist interested in cutaneous protective mechanisms, this guide provides expertly researched chapters on every aspect of stratum corneum structure, function, and development, as well as detailed sections on barrier-repair strategies and the role of barrier function in diseases such as atopic dermatiti |
Contents
| 1 | |
| 5 | |
| 15 | |
From Saran Wrap to Biosensor | 25 |
5 Biochemistry of Human Stratum Corneum Lipids | 33 |
Function Origins and Therapeutic Applications | 43 |
7 Structure of the Skin Barrier | 65 |
8 Cornified Envelope and CorneocyteLipid Envelope | 97 |
19 The Role of the Primary Cytokines TNF IL1 and IL6 in Permeability Barrier Homeostasis | 305 |
Epidermal Liposensors | 319 |
21 Permeability Barrier Homeostasis | 337 |
22 Cutaneous Barriers in Defense Against Microbial Invasion | 363 |
23 The Epidermal Antioxidant Barrier | 379 |
24 Sources and Role of Stratum Corneum Hydration | 399 |
25 Vitamin D and the Epidermis | 427 |
26 Diseases That Affect Barrier Function | 447 |
9 Profilaggrin and the Fused S100 Family of CalciumBinding Proteins | 111 |
10 The Role of Keratins in Epithelial Homeostasis | 141 |
Pivotal Actors in the Stratum Corneum Cohesion and Desquamation | 171 |
Role of Tight Junctions | 191 |
13 What Makes a Good Barrier? Adaptive Features of Vertebrate Integument | 211 |
Measurement Origins and Functions | 223 |
The Final Steps in Barrier Formation | 231 |
16 The Epidermal Lamellar Body as a Multifunctional Secretory Organelle | 261 |
17 Skin Structural Development | 273 |
18 Epidermal Calcium Gradient and the Permeability Barrier | 289 |
27 Pathogenesis of the Barrier Abnormalities in Disorders of Cornification | 469 |
28 Pathogenesis of Desquamation and Permeability Barrier Abnormalities in RXLI | 511 |
29 Prevention and Repair of Barrier Disruption in Occupational Dermatology | 519 |
Basis for Functional Abnormalities | 535 |
The Psychosensory Interface | 553 |
32 The Stratum Corneum of the Epidermis in Atopic Dermatitis | 569 |
Fixing the BarrierTheory and Rational Deployment | 591 |
| 601 | |
Back cover | 613 |
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Common terms and phrases
abnormalities activity addition aged alpha altered appears Arch Dermatol associated atopic dermatitis barrier function barrier homeostasis barrier recovery basal biochemical Biol Chem body calcium cells ceramides changes cholesterol containing corneocytes cornified cultured cutaneous cytokines decreased defective deficiency demonstrated desquamation differentiation disease disruption domain effects Elias PM envelope enzyme epidermal expression extracellular factor fatty acids Feingold Figure filaggrin formation gene gradient human human skin ichthyosis important increased indicating induced Invest Dermatol involved keratin keratinocytes lamellar layers levels lipid localization loricrin loss mechanisms membrane mice molecular mouse mutations normal observed occurs organization patients permeability barrier phase present processing production profilaggrin protein recently receptor reduced regulation repair response role secretion shown skin skin barrier specific sphingomyelinase stimulates stratum corneum stress structure studies suggest surface synthesis Table TEWL tion tissue vivo xerosis