The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs

Front Cover
John Wiley & Sons, Apr 18, 2011 - Medical - 528 pages
The discovery and use of medicines is just as fascinating a human scientific endeavor as space flight or the tracing of human evolution. It is also the everyday task of hundreds of thousands of pharmacists, pharmaceutical chemists and researchers worldwide.
Based on his profound knowledge of past and present paradigms in the development of medicines, Enrique Ravina takes the reader from the very beginnings of pharmacology to the multibillion-dollar business it represents today. Recounting the often spectacular successes and failures of innovative drugs as well as the people who discovered them, he brings abstract science to life in anecdotal form.
For anyone with a more than superficial interest in the science of drugs and all those interested in knowing how drugs have been developed, how they have reached us, and became part of our daily life. This book is beautifully illustrated, containing many rare and historical photographs of drugs and their discoverers, and abounds with references to the primary literature, listing seminal publications alongside more modern reviews for readers seeking further details.

With a Foreword by Hugo Kubinyi
 

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Contents

Evolution of Drug Discovery
1
The First Synthetic Drugs and the Birth of Chemotherapy
23
From Traditional Medicines to Modern Drugs Enrique Ravina
53
Drugs from Natural Products
107
Warfarin and Acenocoumarol
146
Rationalizing the Drug Discovery Process
313
StructureBased Drug Discovery
405
7 Biopharmaceuticals
441
Concluding Remarks
461
Index
467
Copyright

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About the author (2011)

Enrique Ravina studied pharmacy at the University of Santiago de Compostela, Spain, where he obtained his PhD in 1969 and was appointed Professor of Organic Chemistry in 1975. Since 1981 he is Professor of Medicinal/Pharmaceutical Chemistry at the same University. He is a member of the Spanish Royal Academy of Pharmacy, a founding member of the Spanish Society of Medicinal Chemistry and a member of the American Chemical Society. Professor Ravina has over 120 publications to his name in the field of chemistry of drugs, especially in the area of antipsychotic and cardiovascular potential drugs, including a book, book chapters, as well as a co-inventor of the world patent "6-phenyldihydropyrrolopyrimidinedione derivatives".

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