Neuropathology of Focal Epilepsies: An Atlas
Interdisciplinary co-operation between epileptologists, neuroradiologists, psychologists and neurosurgeons is the most fundamental prerequisite for localising and performing targeted resections of epileptogenic foci from patients with focal therapy resistant epilepsy. Worldwide there has been a steady increase in the number of epilepsy surgery centres, and in the number of operations performed on children and babies. A systematic neuropathological description is presented here involving macroscopic and histological findings. In this book, a systematic documentation of characteristic as well as rarer alterations is presented involving 444 patients who had been operated on in Germany between 1990 and 1997 at the Bethel Epilepsy Centre in Bielefeld. It includes 257 patients with temporal lobes (TLE) and 187 patients with extratemporal epilepsy (ETE).
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Introduction and description of the problem
Temporal lobe epilepsy TLK
Summary and characteristics of
Characteristics of individual disease groups and conclusions regarding
abnormal Age at operation amongst amygdala astrocytoma atrophy balloon cells bizarre neurons brain tissue CA4 field cent clinical compartment coronary section cortex cortical dysplasia cortical layer corticomedullary boundary defect dentate gyrus diagnosis Diagram disruption dual pathology Duration of epilepsy electrodes endfolium Engel epileptogenic expression female fibrillary focal frontal lobe ganglioglioma GFAP GFAP preparation glial cell glioneuronal gliosis grade granular cell layer gyration gyri Hemimegalencephaly heterotopia HiFo hippocampal formation hippocampal sclerosis histological imaging infiltration lamination leptomeningeal lesion localisation lymphocytic Macroscopic male massive mesial TL microdysgeneses molecular layer months morphological Neopl neoplasias nerve cell loss neurofilaments neuronal loss neuropathological Nissl staining nodular occipital parahippocampal gyrus perivascular proliferation protein receptor right temporal scar Seizure history seizure onset serial slices structures surgical synaptophysin syndrome Table temporal lobe epilepsy temporal lobe resection tion TL resection tuberous tumour white matter