Melatonin: From Molecules to Therapy

Front Cover
Nova Publishers, 2007 - Medical - 906 pages
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
 

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Contents

Section II Therapeutic Perspectives
481
Pineal Region Tumors
483
Melatonin and Cancer
499
Therapeutic Perspectives of Gastrointestinal Melatonin
529
Endogenous Versus Exogenous Effects of Melatonin
547
Melatonin Circadian Rhythms in Women with Depression Relationship to the Reproductive Cycle
571
Melatonin Therapy of Circadian Rhythm Sleep Disorders in Neurodevelopmentally Disordered Children A Neurological Viewpoint
581
Treatment by Melatonin of a Genetic Disorder SmithMagenis Syndrome
605

Chronobiological Aspects of Melatonin Activity
177
The Molecular Basis to the Circadian Effects of Melatonin
197
Melatonin Effects on Uterine Physiology
207
Melatonin and Human Reproduction Why the Effect is so Elusive?
219
Melatonin Immunomodulatory Signal
227
Photoperiodic vs NonPhotoperiodic Animals Circadian and Seasonal Changes in Immunity
247
Melatonin An Endogenous Antiestrogen with Oncostatic Properties
261
Melatonin and Cancer Basic Research
273
Melatonin in Retinal Pathophysiology
283
The Physiology Pharmacology and Anatomical Distribution of Melatonin Receptors in Visual System Nuclei in the Vertebrate CNS
295
Antioxidant Capacity of the Neurohormone Melatonin
317
Protective Role of Melatonin against Mitochondrial Damage in Inflammation
327
Protective Effects of Melatonin against Hyperhomocysteinemia
349
Photo and Radiation Induced Reactions of Melatonin by Laser Photolysis and Pulse Radioloysis
369
Melatonin Action on Neuropeptide Induction through ReceptorMediated Mechanisms in the Brain
387
Melatonin Receptors in Neuroendocrine Development
401
The Effects of Exogenous Melatonin on the Morphology of Thyrocytes in Pinealectomized and Irradiated Rats
413
The Control of MT Release from Mammalian and Avian Pineal Glands
425
Effect of Chronic Melatonin Administration on Various Physiological Parameters from Old Wistar Rats
457
Melatonin and Sleep in ShiftWorkers
615
Role of Melatonin in the Regulation of Human Circadian Rhythms and Sleep
633
Ramelteon a Selective MT1MT2 Receptor Agonist Provides a Novel Treatment for Insomnia
647
Melatonin Dopamine and Circadian Rhythm in the Restless Legs Syndrome
669
Sleep and Circadian Neuroendocrine Dysregulation in Seasonal Affective Disorder
681
Involvement of Free Radicals and Reactive Oxygen Species in Physiological and Pathological Processes in the Thyroid Gland A Potential Role of Mel...
699
Role of Melatonin in Health and Diseases Headache Disorders
717
Ambient Illumination and Melatonin in the Natural Setting
731
Melatonin Effect on Smooth Muscle and Clinical Utility
753
Melatonin and Woman
759
Effects of Melatonin on the Cardiovascular System
771
Melatonin and Cerebrovascular Disease
785
Melatonin in Focal Cerebral IschaemiaEvidence for Efficacy and Priorities for Future Research
803
Understanding the Role of Melatonin in Epilepsy From Bench to Bedside
813
Role of Melatonin on Alzheimers Disease
827
Longitudinal Measurements of Melatonin Secretion in the Elderly Implications for Alzheimers Disease
841
Interactions of Melatonin with Environmental Factors
849
Index
863
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