Heme Oxygenase: Clinical Applications and Functionshis book provides a comprehensive summary of data from basic research on characterization, regulation, and function of heme oxygenase in mammalian systems. The book also includes a major section that covers the currently used clinical methods to suppress neonatal jaundice with emphasis on the newly developed use of synthetic metalloporophyrins. This book will be welcomed by researchers and students in pharmacology, biochemistry, pharmacy, neonatology, hematology, internal medicine, and endocrinology. |
Contents
Chapter | 1 |
Porphobilinogen Deaminase and Uroporphyrinogen III Synthetase | 24 |
References | 30 |
Chapter 2 | 43 |
Chapter 6 | 46 |
References | 58 |
Enzymatic Degradation of Heme by Heme Oxygenase | 67 |
References | 96 |
Chapter 5 | 145 |
Mechanisms of Heme Oxygenase Regulation | 155 |
References | 180 |
Neonatal Jaundice | 203 |
Toxicity of Bilirubin to the Newborn | 211 |
Possible Physiological Importance of Bilirubin | 219 |
| 253 | |
| 267 | |
Common terms and phrases
8-aminolevulinate Acad adrenal ALA synthetase albumin amino acid Arch bile pigments bilirubin biliverdin reductase binding Biochem Biol Biophys biosynthesis bromobenzene carbon monoxide catabolism cDNA cells cellular Chem Clin cobalt complex concentration cytochrome P-450 Decrease detected drug effect enzymatic enzyme enzyme activity excretion formation fraction glutathione haem heat shock heme degradation heme metabolism heme molecule heme oxygenase activity heme oxygenase isozymes hemin hemoglobin hemopexin hemoproteins hepatic hepatocytes HO-1 gene HO-1 mRNA hyperbilirubinemia hyperthermia induction of heme inhibition isomers isozymes kidney Kikuchi Kutty macrophages Maines mammalian mechanism metal ions metalloporphyrins microsomal microsomal heme oxygenase mitochondrial molecular weight mouse mRNA NADPH NADPH-cytochrome P-450 reductase Natl neonatal newborn nucleotides oxidation oxygen Pharmacol porphyrin Proc production protein protoporphyrin purified rat brain rat HO-1 Rat liver Increase regulation of heme regulatory response Schmid sequence serum bilirubin Sn-protoporphyrin specific spleen studies substrate synthase synthesis testis tissue Trakshel transcription factor vivo Yoshida