From Neuroscience to Neurology: Neuroscience, Molecular Medicine, and the Therapeutic Transformation of NeurologyStephen Waxman The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson's disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone - clinicians and basic scientists alike - interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders. * Presents the evolution of the field of neurology into a therapeutic discipline * Discusses lessons learned from past successes and applications to ongoing work * Explores the future of this field |
Contents
Seeing the Brain So We Can Save | 3 |
Advances in the Acute Treatment | 21 |
Preserving Function in Acute Nervous | 35 |
Copyright | |
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activity acute adult agonists Alzheimer's disease animal models Ann Neurol astrocytes axonal BDNF behavioral blood flow BoNT botulinum toxin brain injury Brain Res calcium cerebral channelopathies clinical trials cortex cortical depression disorders dopamine dopaminergic dorsal dose drug effects epilepsy function GDNF gene delivery gene expression gene therapy genetic glial growth factor hippocampal human imaging improved increased infarct inhibition inhibitors injection ischemia ischemic stroke lesions levodopa mechanisms membrane mice microarray migraine molecular motor multiple sclerosis muscle mutations myelin Natl Acad Sci nerve nervous system neural stem cells neurogenesis Neurology neurons neuropathic pain neuropathy neuroprotective Neurosci Neurosurg neurotrophic factor outcome Parkinson's disease pathways patients peptide peripheral phenotype placebo potential Proc Natl Acad progenitor cells protein receptor recovery reduced regeneration role sensory sodium channel spinal cord injury stem cells stimulation studies subunit surgical symptoms syndrome target therapeutic tion tissue transplantation treatment