Manchester: An Architectural History

Front Cover
Manchester University Press, 2000 - Architecture - 366 pages
0 Reviews
Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites.Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include:challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables novel non-injectable formulation approaches of peptides and proteins chemical vectors for delivery of nucleic acid based drugs viral technology for delivery of nucleic acids the innate immune response, adjuvants and delivery systems solid lipid nanoparticle based systems for delivery of biomacromolecule therapeutics dendrimers in delivery of biopharmaceuticals modification of peptides and proteins nanocarriers for the delivery of peptides and proteins polymer-based delivery systems for oral delivery of peptides and proteins advanced pulmonary delivery of peptide/protein drugs using polymeric particles polymer microparticles for nucleic acid delivery pulmonary delivery of small interfering RNA for novel therapeutics lipid-based formulations for siRNA delivery cellular bioavailability of peptide nucleic acids (PNA) conjugated to cell penetrating peptides DEAE-Dextran-MMA graft copolymer for non-viral delivery of DNA liposomes in adjuvant systems for parenteral delivery of vaccines influenza virosomes as delivery systems for antigens GRAZAX: an oromucosal vaccine for treating immunotheraphy against grass pollen allergy delivery technologies for biopharmaceuticals: a critical assessmentDelivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Housing in the nineteenth century
33
The coming of the railways 17
47
Housing between the wars
153
Housing in the postwar period 189
248
into the twentyfirst century A European city
281
Notes
296
Gazetteer
316
Glossary
345
Index
361
Copyright

Other editions - View all

Common terms and phrases

References to this book

All Book Search results »

Bibliographic information