Immune Response and the EyeJ. Wayne Streilein In this book, the physiologic bases of ocular immune privilege and the distinctive systemic immune responses elicited by eye derived antigens are described. Several chapters discuss the pathogeneses of these disorders which arise from infections, autoimmunity, and neoplasms. Finally, chapters devoted to corneal and retinal transplantation describe attempts to exploit ocular immune privilege to promote graft survival and thereby cure blindness. Ophthalmologists, both clinicians and physician scientists, general and tumor immunologists, transplantation biologists and anyone seeking to understand the immunopathogenic diseases that threaten vision will appreciate the information presented in this book. |
Contents
Allergic Conjunctival Disorders | 5 |
Regional Immunity and Ocular Immune Privilege | 11 |
Afferent Limb | 18 |
Immune Regulation Tolerance and the Immune Reflex | 21 |
Immune Privilege Extreme Regional Immunity | 27 |
Immune Privilege and the Efferent Limb | 33 |
Molecular and Cellular Aspects of Allergic Conjunctivitis | 39 |
Clinical Studies | 45 |
Immunopathogenesis of Viral Ocular Infections | 120 |
Antigen Presentation in the HSV1Infected Cornea | 128 |
References | 134 |
Immune Privilege Tumors and the | 137 |
Preventing Tumor Antigen Recognition by Altering Antigen Processing | 145 |
Immune Privilege within Tumors | 151 |
Immunopathogenic Mechanisms in Intraocular Inflammation | 159 |
Noninfectious | 165 |
Mast Cells and Mast Cell Mediators | 51 |
Anterior ChamberAssociated Immune Deviation | 59 |
Diverging Hypotheses on the Induction and Expression of ACAID | 65 |
Ocular Immunosuppressive Microenvironment | 72 |
aMelanocyteStimulating Hormone | 79 |
Mechanisms of Intraocular Inflammation | 90 |
Inflammatory Mediators | 97 |
Ocular Infection Animal Model | 108 |
Experimental Models | 172 |
Conclusion | 179 |
Immunobiology and Immunopathology of Corneal Transplantation | 186 |
Mechanisms of Rejection of Orthotopic Corneal Allografts | 194 |
Strategy 1 | 200 |
Retinal Transplantation | 207 |
Clinical Implications | 213 |
Common terms and phrases
allergic allogeneic allografts anterior chamber antibodies antigen presenting antigen-specific apoptosis aqueous humor autoimmune disease CD4+ T cells CD8+ cell activation cellular chamber Chan CC chemokines choroidal Clin clinical conjunctiva cornea grafts corneal transplantation Curr Eye Res cytokines dendritic cells downregulation effector T cells endothelial epithelium expression FasL function gene herpes simplex virus human IFN-y immune response immune system immunogenic Immunol immunosuppressive immunosuppressive factors infection infiltration inflammation inflammatory inhibit interleukin-1 intraocular Invest Ophthalmol Kaplan HJ Langerhans leukocytes ligand lymphocytes macrophages mast cells mechanisms mediated melanoma MHC class mice molecular molecules mouse murine neutrophils Niederkorn Niederkorn JY normal Nussenblatt RB ocular microenvironment Ophthalmol Vis Sci orthotopic corneal allografts pathogens patients peptide photoreceptor privileged sites production proliferation protein rats receptor regulatory T cells role specific Streilein JW studies subretinal space suppression T-cell Th1 cells tissue transforming growth tumor tumor antigens tumor cells vitro
References to this book
Auge und Innere Medizin: okuläre Veränderungen bei systemischen Erkankungen Frank W. Tischendorf No preview available - 2004 |