Immune Response and the Eye

Front Cover
J. Wayne Streilein
Karger Medical and Scientific Publishers, Jan 1, 1999 - Medical - 226 pages
In this book, the physiologic bases of ocular immune privilege and the distinctive systemic immune responses elicited by eye derived antigens are described. Several chapters discuss the pathogeneses of these disorders which arise from infections, autoimmunity, and neoplasms. Finally, chapters devoted to corneal and retinal transplantation describe attempts to exploit ocular immune privilege to promote graft survival and thereby cure blindness.
Ophthalmologists, both clinicians and physician scientists, general and tumor immunologists, transplantation biologists and anyone seeking to understand the immunopathogenic diseases that threaten vision will appreciate the information presented in this book.
 

Contents

Allergic Conjunctival Disorders
5
Regional Immunity and Ocular Immune Privilege
11
Afferent Limb
18
Immune Regulation Tolerance and the Immune Reflex
21
Immune Privilege Extreme Regional Immunity
27
Immune Privilege and the Efferent Limb
33
Molecular and Cellular Aspects of Allergic Conjunctivitis
39
Clinical Studies
45
Immunopathogenesis of Viral Ocular Infections
120
Antigen Presentation in the HSV1Infected Cornea
128
References
134
Immune Privilege Tumors and the
137
Preventing Tumor Antigen Recognition by Altering Antigen Processing
145
Immune Privilege within Tumors
151
Immunopathogenic Mechanisms in Intraocular Inflammation
159
Noninfectious
165

Mast Cells and Mast Cell Mediators
51
Anterior ChamberAssociated Immune Deviation
59
Diverging Hypotheses on the Induction and Expression of ACAID
65
Ocular Immunosuppressive Microenvironment
72
aMelanocyteStimulating Hormone
79
Mechanisms of Intraocular Inflammation
90
Inflammatory Mediators
97
Ocular Infection Animal Model
108
Experimental Models
172
Conclusion
179
Immunobiology and Immunopathology of Corneal Transplantation
186
Mechanisms of Rejection of Orthotopic Corneal Allografts
194
Strategy 1
200
Retinal Transplantation
207
Clinical Implications
213
Copyright

Common terms and phrases

Bibliographic information