Movement Disorders: Genetics and Models
Mark S. LeDoux
Elsevier, Jan 25, 2005 - Medical - 824 pages
The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.
* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
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PAROXYSMAL MOVEMENT DISORDERS
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a-synuclein abnormal Acad Sci U S A activity aggregates agonist alpha-synuclein animal models Ann Neurol associated ataxia autosomal basal ganglia behavior Brain Res cerebellar channel chromosome clinical cortex cortical deficits degeneration dopamine dopaminergic doses Drosophila melanogaster drugs dysfunction dyskinesia dystonia dystonic rats DYT1 effects elegans essential tremor expression forelimb frequency function gene genetic genome glycine receptor harmaline human Huntington’s disease hyperekplexia impaired increased induced investigators knock-in l-dopa lesions levodopa limb monkeys motor mouse model Mov Disord movement disorders MPTP muscle mutations myoclonus Natl Acad Sci neurodegeneration Neurology neurons Neurosci nigrostriatal normal nucleus onset oxidative parkin Parkinson Parkinson’s disease Parkinsonian paroxysmal pathology pathway patients phenotype polyQ postural primate Proc Natl Acad progressive supranuclear palsy protein Purkinje cells reflex response rodents rotenone SEGMENT striatal striatum studies substantia nigra subunit symptoms syndrome tics tion torsinA Tourette Tourette syndrome toxicity transgenic transgenic mice treatment wild-type
Page 41 - Zoghbi, HY (1999). Rett syndrome is caused by mutations in X-linked MECP2. encoding methyl-CpG-binding protein 2.
Page 52 - ES 1992. A genetic map of the mouse suitable for typing intraspecific crosses.
Page 53 - Robertson, E., Bradley, A., Kuehn, M., and Evans, M. (1986) Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector.