Genetics of Focal Epilepsies: Clinical Aspects and Molecular BiologyThis volume contains contributions on genetic aspects of a wide range of focal epilepsies. It is based on an international workshop held in Avignon, France in September 1996. Topics covered include: idiopathic age-related focal epilepsies; idiopathic iocal epilepsies in infancy; autosomal dominant focal epilepsies; molecular biology; animals models; and case reports. |
Contents
The discovery of benign rolandic epilepsy | x |
The genetics of benign childhood epilepsy with centrotemporal spikes | 35 |
multifactorial | 57 |
clinical | 73 |
Autosomal dominant nocturnal frontal lobe epilepsy | 81 |
Genetics of autosomal dominant partial epilepsy with auditory features | 95 |
Autosomal dominant rolandic epilepsy with speech dyspraxia | 109 |
The genetics of febrile convulsions and temporal lobe epilepsy | 149 |
Neuronal nicotinic acetylcholine receptor and epilepsy | 187 |
ion channels and paroxysmal disorders of the nervous system | 203 |
Homeobox genes in the developing brain | 215 |
a multifactorial epilepsy model | 229 |
Evidence for supernumerary GABAergic neurons and disinhibition in | 239 |
Genetic predisposition to partial focal seizures and to generalized tonicclonic | 251 |
Transgenic animal models of epilepsy | 261 |
Afterword | 277 |
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Common terms and phrases
activity ADNFLE affected individuals allele Andermann Angelman syndrome associated autosomal dominant autosomal dominant nocturnal BCECTS benign partial epilepsy Berkovic Bertrand brain brainstem brainstem seizures cells cent centro-temporal spikes channel gene chromosome clinical complex partial seizures cortical dentate gyrus disease disorders Dobyns dominant nocturnal frontal Doose EEG trait epilepsy syndromes epileptic epileptiform expression factors familial temporal lobe family history febrile convulsions febrile seizures focal epilepsy foci forebrain seizures frontal lobe epilepsy GABA GABAA receptor GABAergic GAD-immunoreactive genome GEPR-9s gerbils GTCS Guerrini heterotopia hippocampal human ictal idiopathic epilepsy infantile interictal lissencephaly locus lod score mapping markers mice mode of inheritance molecular mouse multifactorial mutation myoclonic nAChRs Neurology neuronal neuronal nicotinic acetylcholine Neurosci nicotinic acetylcholine receptor nocturnal frontal lobe normal onset patients pedigree phenotype probands reading epilepsy region rolandic epilepsy Scheffer sclerosis seizure-resistant seizure-sensitive sharp waves siblings Steinlein subunit susceptibility synaptic temporal lobe epilepsy