Endocrine Tumor Syndromes and Their Genetics
Karger Medical and Scientific Publishers, Mar 20, 2013 - Medical - 200 pages
In these times, a book should aspire to present the most significant advances in the field, reflect the themes of the moment, and provide a useful compendium for future reference. This book accomplishes all three objectives by discussing the changing world of modern genetics in endocrine tumors and its impact on clinical practice. Clinicians have to incorporate modern genetics and systems biology in their daily practice. Educators and researchers have to introduce molecular pathways and their genetic variability in their teaching, as well as understanding of classic physiology and pathophysiology.Taking these aspects into account, the chapters in this book cover both the classic multiple endocrine neoplasia (MEN) syndromes, as well as newly described ones, such as Carney triad and Carney-Stratakis syndrome. Furthermore, the genetics of paragangliomas as well as thyroid, parathyroid, and pituitary tumors are examined. Outlining the latest research and its obvious implications for our understanding the genetics of endocrine tumor formation and molecular biology of cancer and their potential therapeutic implications, this book is not only useful for researchers but even more so for practicing clinicians, in particular internists, endocrinologists, oncologists, pediatricians, surgeons, pathologists, geneticists, and genetic counselors.
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Other editions - View all
activity adrenal adrenocortical allele amino acid associated benign Cancer Res Carney complex CASR CDKN1B cell cycle chromosome Clin Endocrinol Metab clinical codon cyclin cysts develop diagnosis encoding endocrine neoplasia type Endocrine Tumor Syndromes exon FNMTC Front Horm Res function gene mutations Genetics germline mutations gland growth hemangioblastoma Hippel-Lindau disease hormone human hyperplasia identified inactivation Increased expression inhibitor JUND Karger kinase Korbonits lesions malignant MEN1 gene MEN2 MEN2A MEN2B MEN4 menin metastatic mice microRNAs miRNAs missense molecular multiple endocrine neoplasia neoplasms neuroendocrine tumors NFPAs occur ofthe Oncogene p27 protein pancreatic papillary paraganglioma parathyroid adenomas pathway patients phenotype PHEO pheochromocytoma PHPT pituitary adenomas pituitary tumors primary hyperparathyroidism PRKAR1A prolactinomas pulmonary receptor renal cell carcinoma reported RET mutations screening SDHB SDHD signaling somatic mutations somatotroph sporadic Stratakis studies subunit thyroid cancer thyroid carcinoma tion tissues transcription tumor suppressor gene tumor types tumorigenesis variants von Hippel-Lindau disease