Skin Tissue Engineering and Regenerative Medicine
Mohammad Albanna (Author), James H. Holmes IV (Author), TotalBoox (Distributor), TBX (Distributor)
The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. Explores cellular and molecular processes of wound healing, scar formation, and dermal repair Includes examples of animal models for wound healing and translation to the clinical world Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies
Technology & Engineering
1 online resource
9780128017975, 9780128016541, 012801797X, 012801654X
969051456
Front Cover; Skin Tissue Engineering and Regenerative Medicine; Copyright; Dedication; Contents; List of Contributors; Foreword; 1
Anatomy, Physiology, Histology, and Immunohistochemistry of Human Skin; INTRODUCTION; SKIN ANATOMY, HISTOLOGY, AND PHYSIOLOGY; EPIDERMIS; Keratinocytes; Melanocytes; Langerhans Cells; Merkel Cells; DERMOEPIDERMAL JUNCTION; DERMIS; Vasculature; Muscles; Nerves; Skin Appendages; HYPODERMIS; WOUND HEALING AND IMMUNOHISTOCHEMISTRY; Wound Morphometrics; Immunohistochemistry to Define Elements within the Skin; REFERENCES 4
Clinical Management of Wound Healing and Hypertrophic ScarringWOUND HEALING AND THE BIOMEDICAL BURDEN OF ITS DYSFUNCTION; STAGES OF WOUND HEALING; PATHOLOGIC WOUND HEALING; CHRONIC WOUNDS; WOUND HEALING THERAPIES; Negative Pressure Therapy; Cytokines and Growth Factors; Cell-Based Therapy; Biomimetic Scaffolds; FIBROPROLIFERATIVE DISEASE; SCAR REDUCTION THERAPIES; General Approaches; Scar Revision Surgery; Radiotherapy; Laser Therapy; Cryotherapy; Moisture-Retaining Dressings; Antiproliferative Agents; Anti-inflammatory Therapies; Reducing Mechanical Tension; REGENERATIVE HEALING CONCLUSIONLIST OF ABBREVIATIONS; REFERENCES; 5
Process Development and Manufacturing of Human and Animal Acellular Dermal Matrices; INTRODUCTION; CLINICAL NEED; DEVELOPMENT OF ADMS; ADM REQUIREMENTS; PROCESSING METHODOLOGIES; Tissue Acquisition; Animal Dermis; Human Dermis; Decellularization Techniques; Physical Methods; Chemical Methods; Detergents; Acids or Bases; Hypotonic or Hypertonic Treatments; Alcohol and Other Solvents; Biologic Methods; Decellularization Criteria; Crosslinking; Preservation of ADMs; Wet Preservation; Cryopreservation; Freezing; Lyophilization; Sterilization
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